Recombinant Paraponera clavata Delta-paraponeritoxin-Pc1a | CSB-BP340426PCP

Recombinant Paraponera clavata Delta-paraponeritoxin-Pc1a | CSB-BP340426PCP | Cusabio

Alternative Name(s): Pac-TX

Gene Names: N/A

Research Areas: Others

Organism: Paraponera clavata (Bullet ant) (Izuela)

AA Sequence: FLPLLILGSLLMTPPVIQAIHDAQR

Source: Baculovirus

Tag Info: N-terminal 6xHis-tagged

Expression Region: 1-25aa

Sequence Info: Full Length

MW: 3.7 kDa

Purity: Greater than 90% as determined by SDS-PAGE.

Relevance: Blocks nicotinic synaptic transmission in insect CNS and affects voltage-gated sodium channels (Nav). It is a strong, but very slowly acting agonist for smooth muscles and its blocks synaptic transmission in the insect CNS in a concentration-dependent manner and depolarizes giant interneurons. Also affects neuromuscular transmission in rat tissue.

Reference: "Pharmacological characterization and chemical fractionation of the venom of the ponerine ant, Paraponera clavata (F.)." Piek T., Hue B., Mantel P., Nakajima T., Schmidt J.O. Comp. Biochem. Physiol. 99C:481-486(1991)

Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20?/-80?. The shelf life of lyophilized form is 12 months at -20?/-80?.

Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week.

Function: Blocks nicotinic synaptic transmission in insect CNS and affects voltage-gated sodium channels (Nav). It is a strong, but very slowly acting agonist for smooth muscles and its blocks synaptic transmission in the insect CNS in a concentration-dependent manner and depolarizes giant interneurons. Also affects neuromuscular transmission in rat tissue.

Involvement in disease:

Subcellular Location: Secreted

Protein Families:

Tissue Specificity: Expressed by the venom gland.

Paythway:

Form: Liquid or Lyophilized powder

Buffer: If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.

Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20?/-80?. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Uniprot ID: P41736

HGNC Database Link: N/A

UniGene Database Link: N/A

KEGG Database Link: N/A

STRING Database Link: N/A

OMIM Database Link: N/A