Recombinant Mouse Protein FAM83D (Fam83d) | CSB-YP866701MO

Recombinant Mouse Protein FAM83D (Fam83d) | CSB-YP866701MO | Cusabio

Alternative Name(s): Fam83dProtein FAM83D

Gene Names: Fam83d

Research Areas: Cancer

Organism: Mus musculus (Mouse)

AA Sequence: MAARFELLDDLPAACLSPCGPPNPTELFSEARRLALEQLLAGGPDAWAAFLRRERLGRFLNADEVREVLGAAERPGEDGAAVAEDSFGSSHECSSGTYFPEQSDLEPPALELGWPSFYQGAYRGATRVEAHFQPRGAGAGGPYGCKDALRQQLRSAREVIAVVMDVFSDIDIFRDLQESCRKRGVAVYILLDQTLLPHFLDMCMDLRVHPEQEKLMTVRTITGNIYYARSGTKVVGKVHEKFTLIDGIRVATGSYSFTWTDGKLNSSNLVILSGQVVEHFDLEFRILYAQSEPISSKLLSNFQINSKFDHLADRKPQSKEPTLGNLLRMRLARLSSTPRKSNLGPEEPPKDRAKPKRPDSEASTISDEDYFHSHKDQLEDSKVADAATQTEPREEMAAVSLSEVGTQTSSSMMCVGTQTTVVTRAASSQATVWSKSTTTQTEADESFLPQGAQSKEGSPASKMSVSRSSSVRSSSSVSSQGSLASSVSSHVSLTAADLHTPAYPKYLGLGTPHLDLCLRDSFRNLSKERQVHFTGIRSRLTQMLTVLSRRTLFTEHYLSYSPGSFTRASTNLVSVRDIALYPPYQ

Source: Yeast

Tag Info: N-terminal 6xHis-tagged

Expression Region: 1-585aa

Sequence Info: Full Length

MW: 66.3 kDa

Purity: Greater than 90% as determined by SDS-PAGE.

Relevance: Required for proper chromosome congression and alignment during mitosis. Required for targeting KIF22/KID to the spindle microtubules

Reference: "The transcriptional landscape of the mammalian genome."Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. Hayashizaki Y.Science 309:1559-1563(2005)

Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20?/-80?. The shelf life of lyophilized form is 12 months at -20?/-80?.

Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week.

Function: Probable proto-oncogene that regulates cell proliferation, growth, migration and epithelial to mesenchymal transition. Through the degradation of FBXW7, may act indirectly on the expression and downstream signaling of MTOR, JUN and MYC. May play also a role in cell proliferation through activation of the ERK1/ERK2 signaling cascade. May also be important for proper chromosome congression and alignment during mitosis through its interaction with KIF22.

Involvement in disease:

Subcellular Location: Cytoplasm, Cytoplasm, cytoskeleton, spindle, Cytoplasm, cytoskeleton, spindle pole

Protein Families: FAM83 family

Tissue Specificity:

Paythway:

Form: Liquid or Lyophilized powder

Buffer: If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.

Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20?/-80?. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Uniprot ID: Q9D7I8

HGNC Database Link: N/A

UniGene Database Link: UniGene

KEGG Database Link: KEGG

STRING Database Link: STRING

OMIM Database Link: N/A