Recombinant Mouse C-type lectin domain family 12 member A (Clec12a), partial | CSB-EP709488MO

Recombinant Mouse C-type lectin domain family 12 member A (Clec12a), partial | CSB-EP709488MO | Cusabio

Alternative Name(s): C-type lectin-like molecule 1(CLL-1) (Myeloid inhibitory C-type lectin-like receptor) (MICL) ( Micl)

Gene Names: Clec12a

Research Areas: Others

Organism: Mus musculus (Mouse)

AA Sequence: YTTLATEMIKSNQLQRAKEELQENVFLQLKHNLNSSKKIKNLSAMLQSTATQLCRELYSKEPEHKCKPCPKGSEWYKDSCYSQLNQYGTWQESVMACSARNASLLKVKNKDVLEFIKYKKLRYFWLALLPRKDRTQYPLSEKMFLSEESERSTDDIDKKYCGYIDRVNVYYTYCTDENNIICEETASKVQLESVLNGLPEDSR

Source: E.coli

Tag Info: N-terminal 10xHis-tagged and C-terminal Myc-tagged

Expression Region: 65-267aa

Sequence Info: Partial

MW: 30.8 kDa

Purity: Greater than 85% as determined by SDS-PAGE.

Relevance: Cell surface receptor that modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases.

Reference: "Clec12a is an inhibitory receptor for uric acid crystals that regulates inflammation in response to cell death." Neumann K., Castineiras-Vilarino M., Hockendorf U., Hannesschlager N., Lemeer S., Kupka D., Meyermann S., Lech M., Anders H.J., Kuster B., Busch D.H., Gewies A., Naumann R., Gross O., Ruland J. Immunity 40:389-399(2014)

Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20?/-80?. The shelf life of lyophilized form is 12 months at -20?/-80?.

Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week.

Function: Cell surface receptor that modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases.

Involvement in disease:

Subcellular Location: Cell membrane, Single-pass type II membrane protein

Protein Families:

Tissue Specificity:

Paythway:

Form: Liquid or Lyophilized powder

Buffer: If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.

Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20?/-80?. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Uniprot ID: Q504P2

HGNC Database Link: N/A

UniGene Database Link: UniGene

KEGG Database Link: KEGG

STRING Database Link: STRING

OMIM Database Link: N/A