Recombinant Macaca mulatta Erythropoietin (EPO) | CSB-MP007743MOW
- 18 - 28 Working Days
Recombinant Macaca mulatta Erythropoietin (EPO) | CSB-MP007743MOW | Cusabio
Alternative Name(s): EPO; Erythropoietin
Gene Names: EPO
Research Areas: Signal Transduction
Organism: Macaca mulatta (Rhesus macaque)
AA Sequence: APPRLVCDSRVLERYLLEAKEAENVTMGCSESCSLNENITVPDTKVNFYAWKRIEVGQQAVEVWQGLALLSEAVLRGQAVLANSSQPFEPLQLHMDKAISGLRSITTLLRALGAQEAISLPDAASAAPLRTITADTFCKLFRVYSNFLRGKLKLYTGEACRRGDR
Source: Mammalian cell
Tag Info: N-terminal 6xHis-tagged
Expression Region: 28-192aa
Sequence Info: Full Length of Mature Protein
MW: 22.2 kDa
Purity: Greater than 90% as determined by SDS-PAGE.
Relevance: Erythropoietin is the principal hormone involved in the regulation of erythrocyte differentiation and the maintenance of a physiological level of circulating erythrocyte mass.
Reference: "Erythropoietin structure-function relationships: high degree of sequence homology among mammals."Wen D., Boissel J.-P.R., Tracy T.E., Gruninger R.H., Mulcahy L.S., Czelusniak J., Goodman M., Bunn H.F.Blood 82:1507-1516(1993)
Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20?/-80?. The shelf life of lyophilized form is 12 months at -20?/-80?.
Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week.
Function: Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3.
Involvement in disease:
Subcellular Location: Secreted
Protein Families: EPO/TPO family
Tissue Specificity: Produced by kidney or liver of adult mammals and by liver of fetal or neonatal mammals.
Form: Liquid or Lyophilized powder
Buffer: If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20?/-80?. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Uniprot ID: Q28513
HGNC Database Link: N/A
UniGene Database Link: UniGene
KEGG Database Link: KEGG
STRING Database Link: STRING
OMIM Database Link: N/A