Recombinant Human Tumor necrosis factor receptor superfamily member 13C protein (TNFRSF13C) (Active) | CSB-AP002181HU

Recombinant Human Tumor necrosis factor receptor superfamily member 13C protein (TNFRSF13C) (Active) | CSB-AP002181HU | Cusabio

Protein Description: Partial

Alternative Name (s) : B-cell-activating factor receptor, BAFF-R, BLyS receptor 3, CD antigen CD268,

Gene Names: TNFRSF13C,BAFFR,BR3

Research Areas: Cancer

Species: Homo sapiens (Human)

Source: E.Coli

Tag Info: Tag-Free

Expression Region: 1-76aa

Sequence Info: MRRGPRSLRG RDAPAPTPCV PAECFDLLVR HCVACGLLRT PRPKPAGASS PAPRTALQPQ ESVGAGAGEA ALPLPG

Biological Activity: Fully biologically active when compared to standard. The ED50 as determined by its ability to block BAFF induced mouse splenocyte survival is 1.0-5.0 µg/ml in the presence of 1.0 μg/ml of rHuBAFF.

MW: 7.8 kDa

Purity: >95% as determined by SDS-PAGE.

Endotoxin: Less than 1.0 EU/µg as determined by LAL method.

Relevance: B-cell receptor specific for TNFSF13B/TALL1/BAFF/BLyS. Promotes the survival of mature B-cells and the B-cell response. {ECO:0000269|PubMed:11591325, ECO:0000269|PubMed:12387744}.

PubMed ID: 11509692; 10591208; 11591325; 12387744; 12755599; 12721620; 12715002; 16840730; 16160919; 19666484

Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.

Function: B-cell receptor specific for TNFSF13B/TALL1/BAFF/BLyS. Promotes the survival of mature B-cells and the B-cell response.

Involvement in disease: Immunodeficiency, common variable, 4 (CVID4)

Subcellular Location: Membrane, Single-pass type III membrane protein

Protein Families:

Tissue Specificity: Highly expressed in spleen and lymph node, and in resting B-cells. Detected at lower levels in activated B-cells, resting CD4+ T-cells, in thymus and peripheral blood leukocytes.

Paythway: NF-kappaBsignalingpathway

Form: Lyophilized powder

Buffer: Lyophilized from a 0.2 µm filtered 20 mM PB, pH 8.0, 500 mM NaCl

Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Uniprot ID: Q96RJ3

Uniprot Entry Name: TR13C_HUMAN

HGNC Database Link: HGNC

UniGene Database Link: UniGene

KEGG Database Link: KEGG

STRING Database Link: STRING

OMIM Database Link: OMIM