Recombinant Human Trefoil factor 3 protein (TFF3) (Active) | CSB-AP000361HU

Recombinant Human Trefoil factor 3 protein (TFF3) (Active) | CSB-AP000361HU | Cusabio

Protein Description: Full Length of Mature Protein

Alternative Name (s) : Intestinal trefoil factor, Polypeptide P1.B, hP1.B

Gene Names: TFF3,ITF,TFI

Research Areas: Signal Transduction

Species: Homo sapiens (Human)

Source: E.Coli

Tag Info: Tag-Free

Expression Region: 22-80aa

Sequence Info: EEYVGLSANQ CAVPAKDRVD CGYPHVTPKE CNNRGCCFDS RIPGVPWCFK PLQEAECTF

Biological Activity: Fully biologically active when compared to standard. The ED50 as determined by a chemotaxis bioassay using human MCF-7 cells is less than 10 μg/ml, corresponding to a specific activity of ＞ 100 IU/mg.

MW: 6.6 kDa

Purity: >97% as determined by SDS-PAGE and HPLC.

Endotoxin: Less than 1.0 EU/µg as determined by LAL method.

Relevance: Involved in the maintenance and repair of the intestinal mucosa. Promotes the mobility of epithelial cells in healing processes (motogen) . {ECO:0000269|PubMed:11694446}.

PubMed ID: 8346203; 9070946; 10950923; 10830953; 15489334; 14637006; 8454642; 15340161; 19670903; 10824705; 11694446; 18209; 14690424

Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.

Function: Involved in the maintenance and repair of the intestinal mucosa. Promotes the mobility of epithelial cells in healing processes (motogen) .

Involvement in disease:

Subcellular Location: Secreted, extracellular space, extracellular matrix, Cytoplasm

Protein Families:

Tissue Specificity: Expressed in goblet cells of the intestines and colon (at protein level) . Expressed by goblet cells of small and large intestinal epithelia and also by the uterus. Also expressed in the hypothalamus where it is detected in paraventricular, periventricular and supraoptic nuclei (at protein level) .

Paythway:

Form: Lyophilized powder

Buffer: Lyophilized from a 0.2 µm filtered 20 mM PB, pH 7.4, 150mM NaCl

Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Uniprot ID: Q07654

Uniprot Entry Name: TFF3_HUMAN

HGNC Database Link: HGNC

UniGene Database Link: UniGene

KEGG Database Link: KEGG

STRING Database Link: STRING

OMIM Database Link: OMIM