Cusabio Human Recombinants
Recombinant Human T-lymphocyte activation antigen CD80 (CD80) | CSB-CF1054HU
- SKU:
- CSB-CF1054HU
- Availability:
- 18 - 23 Working Days
Description
Recombinant Human T-lymphocyte activation antigen CD80 (CD80) | CSB-CF1054HU | Cusabio
Alternative Name(s): Activation B7-1 antigen BB1 CTLA-4 counter-receptor B7.1
Gene Names: CD80
Research Areas: Immunology
Organism: Homo sapiens (Human)
AA Sequence: VIHVTKEVKEVATLSCGHNVSVEELAQTRIYWQKEKKMVLTMMSGDMNIWPEYKNRTIFDITNNLSIVILALRPSDEGTYECVVLKYEKDAFKREHLAEVTLSVKADFPTPSISDFEIPTSNIRRIICSTSGGFPEPHLSWLENGEELNAINTTVSQDPETELYAVSSKLDFNMTTNHSFMCLIKYGHLRVNQTFNWNTTKQEHFPDNLLPSWAITLISVNGIFVICCLTYCFAPRCRERRRNERLRRESVRPV
Source: in vitro E.coli expression system
Tag Info: N-terminal 10xHis-tagged
Expression Region: 35-288aa
Sequence Info: Full Length of Mature Protein
MW: 32.8 kDa
Purity: Greater than 85% as determined by SDS-PAGE.
Relevance: Involved in the costimulatory signal essential for T-lymphocyte activation. T-cell proliferation and cytokine production is induced by the binding of CD28, binding to CTLA-4 has opposite effects and inhibits T-cell activation. (Microbial infection) Acts as a receptor for adenovirus subgroup B.
Reference: "B7, a new member of the Ig superfamily with unique expression on activated and neoplastic B cells." Freeman G.J., Freedman A.S., Segil J.M., Lee G., Whitman J.F., Nadler L.M. J. Immunol. 143:2714-2722(1989)
Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20?/-80?. The shelf life of lyophilized form is 12 months at -20?/-80?.
Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week.
Function: Involved in the costimulatory signal essential for T-lymphocyte activation. T-cell proliferation and cytokine production is induced by the binding of CD28, binding to CTLA-4 has opposite effects and inhibits T-cell activation.
Involvement in disease:
Subcellular Location: Membrane, Single-pass type I membrane protein
Protein Families:
Tissue Specificity: Expressed on activated B-cells, macrophages and dendritic cells.
Paythway: Toll-likereceptorsignalingpathway
Form: Liquid or Lyophilized powder
Buffer: If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20?/-80?. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Uniprot ID: P33681
HGNC Database Link: HGNC
UniGene Database Link: UniGene
KEGG Database Link: KEGG
STRING Database Link: STRING
OMIM Database Link: OMIM