Recombinant Human Substance-P receptor (TACR1), partial | CSB-EP023068HU

Recombinant Human Substance-P receptor (TACR1), partial | CSB-EP023068HU | Cusabio

Alternative Name(s): NK-1 receptor ;NK-1RTachykinin receptor 1

Gene Names: TACR1

Research Areas: Neuroscience

Organism: Homo sapiens (Human)

AA Sequence: MDNVLPVDSDLSPNISTNTSEPNQFVQPA

Source: E.coli

Tag Info: N-terminal GST-tagged

Expression Region: 1-29aa

Sequence Info: Partial

MW: 30.1 kDa

Purity: Greater than 90% as determined by SDS-PAGE.

Relevance: This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger syst. The rank order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin-K.

Reference: Molecular cloning, structural characterization and functional expression of the human substance P receptor.Takeda Y., Chou K.B., Takeda J., Sachais B.S., Krause J.E.Biochem. Biophys. Res. Commun. 179:1232-1240(1991)

Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20?/-80?. The shelf life of lyophilized form is 12 months at -20?/-80?.

Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week.

Function: This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is

Involvement in disease:

Subcellular Location: Cell membrane, Multi-pass membrane protein

Protein Families: G-protein coupled receptor 1 family

Tissue Specificity:

Paythway: Calciumsignalingpathway

Form: Liquid or Lyophilized powder

Buffer: If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.

Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20?/-80?. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Uniprot ID: P25103

HGNC Database Link: HGNC

UniGene Database Link: UniGene

KEGG Database Link: KEGG

STRING Database Link: STRING

OMIM Database Link: OMIM