Cusabio Active Proteins
Recombinant Human Somatotropin protein (GH1) (Active) | CSB-AP000011HU
- 5 to 10 Working Days
Recombinant Human Somatotropin protein (GH1) (Active) | CSB-AP000011HU | Cusabio
Protein Description: Full Length of Mature Protein
Alternative Name (s) : Growth hormone, GH-N, Growth hormone 1, Pituitary growth hormone,
Gene Names: GH1
Research Areas: Signal Transduction
Species: Homo sapiens (Human)
Tag Info: Tag-Free
Expression Region: 27-127aa
Sequence Info: FPTIPLSRLF DNAMLRAHRL HQLAFDTYQE FEEAYIPKEQ KYSFLQNPQT SLCFSESIPT PSNREETQQK SNLELLRISL LLIQSWLEPV QFLRSVFANS LVYGASDSNV YDLLKDLEEG IQTLMGRLED GSPRTGQIFK QTYSKFDTNS HNDDALLKNY GLLYCFRKDM DKVETFLRIV QCRSVEGSCG F
Biological Activity: Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using rat Nb2-11 lymphoma cells is less than 0.1 ng/ml, corresponding to a specific activity of ＞ 1.0 × 107 IU/mg.
MW: 22.0 kDa
Purity: >98% as determined by SDS-PAGE and HPLC.
Endotoxin: Less than 1.0 EU/µg as determined by LAL method.
Relevance: Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues.
PubMed ID: 386281; 377496; 6269091; 7169009; 2744760; 18473352; 16625196; 10931946; 15489334; 3912261; 5810834; 5144027; 4675454; 5279046; 5279528; 7462247; 7356479; 7028740; 8364549; 14997482; 10393484; 16807684; 3447173; 1549776; 7984244; 8943276; 8552145; 9152628; 9276733; 10391209; 11502836; 12655557; 15001589; 15713716; 17519310
Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Function: Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues.
Involvement in disease: Growth hormone deficiency, isolated, 1A (IGHD1A) ; Growth hormone deficiency, isolated, 1B (IGHD1B) ; Kowarski syndrome (KWKS) ; Growth hormone deficiency, isolated, 2 (IGHD2)
Subcellular Location: Secreted
Protein Families: Somatotropin/prolactin family
Form: Lyophilized powder
Buffer: Lyophilized from a 0.2 µm filtered PBS, pH 7.4
Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Uniprot ID: P01241
Uniprot Entry Name: SOMA_HUMAN
HGNC Database Link: HGNC
UniGene Database Link: UniGene
KEGG Database Link: KEGG
STRING Database Link: STRING
OMIM Database Link: OMIM