Recombinant Human Rhomboid-related protein 2 (RHBDL2), partial | CSB-EP019672HU

Recombinant Human Rhomboid-related protein 2 (RHBDL2), partial | CSB-EP019672HU | Cusabio

Alternative Name(s): Rhomboid-like protein 2

Gene Names: RHBDL2

Research Areas: Others

Organism: Homo sapiens (Human)

AA Sequence: MNLNMGREMKEELEEEEKMREDGGGKDRAKSKKVHRIVSKWMLPEKSRGTYLERANCFPPPVFIISISLAELAVFIYYAVWKPQKQWITLDTGILESPFIYSPEKREEAWRFISYMLVHAG

Source: E.coli

Tag Info: N-terminal 6xHis-tagged

Expression Region: 12-132aa

Sequence Info: Partial

MW: 18.2 kDa

Purity: Greater than 90% as determined by SDS-PAGE.

Relevance: Involved in regulated intrambrane proteolysis and the subsequent release of functional polypeptides from their mbrane anchors. Known substrate: EFNB3.

Reference: The processing of human rhomboid intramembrane serine protease RHBDL2 is required for its proteolytic activity.Lei X., Li Y.M.J. Mol. Biol. 394:815-825(2009)

Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20?/-80?. The shelf life of lyophilized form is 12 months at -20?/-80?.

Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week.

Function: Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors. Known substrate

Involvement in disease:

Subcellular Location: Rhomboid-related protein 2, C-terminal fragment: Cell membrane, Multi-pass membrane protein

Protein Families: Peptidase S54 family

Tissue Specificity:

Paythway:

Form: Liquid or Lyophilized powder

Buffer: If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.

Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20?/-80?. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Uniprot ID: Q9NX52

HGNC Database Link: HGNC

UniGene Database Link: UniGene

KEGG Database Link: KEGG

STRING Database Link: STRING

OMIM Database Link: OMIM