Recombinant Human Protein NOV homolog protein (NOV) (Active) | CSB-AP002511HU

Recombinant Human Protein NOV homolog protein (NOV) (Active) | CSB-AP002511HU | Cusabio

Protein Description: Full Length of Mature Protein

Alternative Name (s) : NovH, Insulin-like growth factor-binding protein 9, IBP-9, IGF-binding protein 9, IGFBP-9

Gene Names: NOV,CCN3,IGFBP9,NOVH

Research Areas: Immunology

Species: Homo sapiens (Human)

Source: E.Coli

Tag Info: Tag-Free

Expression Region: 28-357aa

Sequence Info: M+QVAATQRCP PQCPGRCPAT PPTCAPGVRA VLDGCSCCLV CARQRGESCS DLEPCDESSG LYCDRSADPS NQTGICTAVE GDNCVFDGVI YRSGEKFQPS CKFQCTCRDG QIGCVPRCQL DVLLPEPNCP APRKVEVPGE CCEKWICGPD EEDSLGGLTL AAYRPEATLG VEVSDSSVNC IEQTTEWTAC SKSCGMGFST RVTNRNRQCE MLKQTRLCMV RPCEQEPEQP TDKKGKKCLR TKKSLKAIHL QFKNCTSLHT YKPRFCGVCS DGRCCTPHNT KTIQAEFQCS PGQIVKKPVM VIGTCTCHTN CPKNNEAFLQ ELELKTTRGK M

Biological Activity: Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using murine Balb/c 3T3 cells is less than 1.0 μg/ml, corresponding to a specific activity of ＞ 1000 IU/mg.

MW: 36.2 kDa

Purity: >95% as determined by SDS-PAGE and HPLC.

Endotoxin: Less than 1.0 EU/µg as determined by LAL method.

Relevance: Immediate-early protein likely to play a role in cell growth regulation. {ECO:0000250}.

PubMed ID: 7520150; 8622864; 14702039; 15489334; 1756408; 15340161; 9927660

Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.

Function: Immediate-early protein playing a role in various cellular processes including proliferation, adhesion, migration, differentiation and survival

Involvement in disease:

Subcellular Location: Secreted, Cytoplasm, Cell junction, gap junction

Protein Families: CCN family

Tissue Specificity: Expressed in endiothelial cells (at protein level) (PubMed:21063504) . Expressed in bone marrow, thymic cells and nephroblastoma. Increased expression in Wilms tumor of the stromal type.

Paythway:

Form: Lyophilized powder

Buffer: Lyophilized from a 0.2 µm filtered PBS, pH 7.0

Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Uniprot ID: P48745

Uniprot Entry Name: NOV_HUMAN

HGNC Database Link: HGNC

UniGene Database Link: UniGene

KEGG Database Link: KEGG

STRING Database Link: STRING

OMIM Database Link: OMIM