Recombinant Human Protein GPR15L (GPR15L) | CSB-EP744262HU

Recombinant Human Protein GPR15L (GPR15L) | CSB-EP744262HU | Cusabio

Alternative Name(s): Antimicrobial peptide with 57 amino acid residues (AP-57) (Antimicrobial peptide-57) (Colon-derived SUSD2 binding factor) (CSBF) (Secreted protein C10orf99) (C10orf99)

Gene Names: GPR15L

Research Areas: Others

Organism: Homo sapiens (Human)

AA Sequence: KRRPAKAWSGRRTRLCCHRVPSPNSTNLKGHHVRLCKPCKLEPEPRLWVVPGALPQV

Source: E.coli

Tag Info: N-terminal 10xHis-tagged and C-terminal Myc-tagged

Expression Region: 25-81aa

Sequence Info: Full Length of Mature Protein

MW: 14.0 kDa

Purity: Greater than 85% as determined by SDS-PAGE.

Relevance: Chemotactic factor that mediates lymphocytes recruitement to epithelia through binding and activation of the G-protein coupled receptor GPR15. May be a tumor suppressor; together with SUSD2 has a growth inhibitory effect on colon cancer cells which includes G1 cell cycle arrest.

Reference: "CSBF/C10orf99, a novel potential cytokine, inhibits colon cancer cell growth through inducing G1 arrest." Pan W., Cheng Y., Zhang H., Liu B., Mo X., Li T., Li L., Cheng X., Zhang L., Ji J., Wang P., Han W. Sci. Rep. 4:6812-6812(2014)

Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20?/-80?. The shelf life of lyophilized form is 12 months at -20?/-80?.

Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week.

Function:

Involvement in disease:

Subcellular Location:

Protein Families:

Tissue Specificity:

Paythway:

Form: Liquid or Lyophilized powder

Buffer: If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.

Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20?/-80?. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Uniprot ID: Q6UWK7

HGNC Database Link: N/A

UniGene Database Link: N/A

KEGG Database Link: N/A

STRING Database Link: N/A

OMIM Database Link: N/A