Recombinant Human Proteasome activator complex subunit 2 (PSME2) | CSB-RP011344h

Recombinant Human Proteasome activator complex subunit 2 (PSME2) | CSB-RP011344h | Cusabio

Alternative Name(s): 11S regulator complex subunit beta ;REG-betaActivator of multicatalytic protease subunit 2;Proteasome activator 28 subunit beta ;PA28b ;PA28beta

Gene Names: PSME2

Research Areas: Cell Biology

Organism: Homo sapiens (Human)

AA Sequence: AKPCGVRLSGEARKQVEVFRQNLFQEAEEFLYRFLPQKIIYLNQLLQEDSLNVADLTSLRAPLDIPIPDPPPKDDEMETDKQEKKEVHKCGFLPGNEKVLSLLALVKPEVWTLKEKCILVITWIQHLIPKIEDGNDFGVAIQEKVLERVNAVKTKVEAFQTTISKYFSERGDAVAKASKETHVMDYRALVHERDEAAYGELRAMVLDLRAFYAELYHIISSNLEKIVNPKGEEKPSMY

Source: E.coli

Tag Info: N-terminal GST-tagged

Expression Region: 2-239aa

Sequence Info: Full Length of Mature Protein

MW: 54.3 kDa

Purity: Greater than 90% as determined by SDS-PAGE.

Relevance: Implicated in immunoproteasome assbly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome.

Reference: Organization of the genes encoding the human proteasome activators PA28alpha and beta.McCusker D., Wilson M., Trowsdale J.Immunogenetics 49:438-445(1999)

Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20?/-80?. The shelf life of lyophilized form is 12 months at -20?/-80?.

Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week.

Function: Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome.

Involvement in disease:

Subcellular Location:

Protein Families: PA28 family

Tissue Specificity:

Paythway: Antigenprocessingandpresentation

Form: Liquid or Lyophilized powder

Buffer: If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.

Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20?/-80?. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Uniprot ID: Q9UL46

HGNC Database Link: HGNC

UniGene Database Link: UniGene

KEGG Database Link: KEGG

STRING Database Link: STRING

OMIM Database Link: OMIM