Recombinant Human Parathyroid hormone protein (PTH) (Active) | CSB-AP000051HU

Recombinant Human Parathyroid hormone protein (PTH) (Active) | CSB-AP000051HU | Cusabio

Protein Description: Full Length of Mature Protein

Alternative Name (s) : PTH, Parathyrin

Gene Names: PTH

Research Areas: Signal Transduction

Species: Homo sapiens (Human)

Source: E.Coli

Tag Info: Tag-Free

Expression Region: 32-115aa

Sequence Info: SVSEIQLMHN LGKHLNSMER VEWLRKKLQD VHNFVALGAP LAPRDAGSQR PRKKEDNVLV ESHEKSLGEA DKADVNVLTK AKSQ

Biological Activity: Fully biologically active when compared to standard. The ED50 as determined by its ability to induce cAMP accumulation in murine MC3T3E1 cells is less than 50 ng/ml, corresponding to a specific activity of ＞ 2.0 × 104 IU/mg.

MW: 9.4 kDa

Purity: >97% as determined by SDS-PAGE and HPLC.

Endotoxin: Less than 1.0 EU/µg as determined by LAL method.

Relevance: PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells. {ECO:0000269|PubMed:21076856}.

PubMed ID: 6950381; 6220408; 15489334; 7829495; 4833516; 15340161; 4521809; 728431; 1125201; 4474131; 4721748; 21076856; 2069952; 8344299; 7797503; 10623601; 10837469; 18375760; 2212001; 10523031; 18056632

Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.

Function: PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells.

Involvement in disease: Hypoparathyroidism, familial isolated (FIH)

Subcellular Location: Secreted

Protein Families: Parathyroid hormone family

Tissue Specificity:

Paythway:

Form: Lyophilized powder

Buffer: Lyophilized from a 0.2 µm filtered PBS, pH 7.4

Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Uniprot ID: P01270

Uniprot Entry Name: PTHY_HUMAN

HGNC Database Link: HGNC

UniGene Database Link: UniGene

KEGG Database Link: KEGG

STRING Database Link: STRING

OMIM Database Link: OMIM