Recombinant Human Paraneoplastic antigen Ma2 (PNMA2), partial | CSB-EP018267HUa2
- 3 - 7 Working Days
Recombinant Human Paraneoplastic antigen Ma2 (PNMA2), partial | CSB-EP018267HUa2 | Cusabio
Alternative Name(s): 40KDA neuronal protein Onconeuronal antigen Ma2 Paraneoplastic neuronal antigen MM2
Gene Names: PNMA2
Research Areas: Tags & Cell Markers
Organism: Homo sapiens (Human)
AA Sequence: ALALLEDWCRIMSVDEQKSLMVTGIPADFEEAEIQEVLQETLKSLGRYRLLGKIFRKQENANAVLLELLEDTDVSAIPSEVQGKGGVWKVIFKTPNQDTEFLERLNLFLEKEGQTVSGMFRALGQEGVSPATVPCISPELLAHLLGQAMAHAPQPLLPMRYRKLRVFSGSAVPAPEEESFEVWLEQATEIVKEWPVTEAEKKRWLAESLRGPALDLMHIVQADNPSISVEECLEAFKQVFGSLESRRTAQVRYLKTYQEEGEKVSAYVLRLETLLRRAVEKRAIPRRIADQVRLEQVMAGATLNQMLWCRLRELKDQGPPPSFLELMKVIREEEEEEASFENESIEEPEERDGYGRWNHE
Tag Info: N-terminal 6xHis-SUMO-tagged
Expression Region: 2-361aa
Sequence Info: Partial
MW: 57.1 kDa
Purity: Greater than 85% as determined by SDS-PAGE.
Relevance: Antibodies against PNMA2 are present in sera from patients suffering of paraneoplastic neurological disorders.
Reference: "A serologic marker of paraneoplastic limbic and brain-stem encephalitis in patients with testicular cancer." Voltz R., Gultekin S.H., Rosenfeld M.R., Gerstner E., Eichen J., Posner J.B., Dalmau J. N. Engl. J. Med. 340:1788-1795(1999)
Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20?/-80?. The shelf life of lyophilized form is 12 months at -20?/-80?.
Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week.
Involvement in disease:
Subcellular Location: Nucleus, nucleolus
Protein Families: PNMA family
Tissue Specificity: Brain-specific. In some cancer patients, specifically expressed by testicular tumor cells.
Form: Liquid or Lyophilized powder
Buffer: If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20?/-80?. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Uniprot ID: Q9UL42
HGNC Database Link: HGNC
UniGene Database Link: UniGene
KEGG Database Link: KEGG
STRING Database Link: STRING
OMIM Database Link: OMIM