Recombinant Human Paraneoplastic antigen Ma2 (PNMA2), partial | CSB-EP018267HUa2

Recombinant Human Paraneoplastic antigen Ma2 (PNMA2), partial | CSB-EP018267HUa2 | Cusabio

Alternative Name(s): 40KDA neuronal protein Onconeuronal antigen Ma2 Paraneoplastic neuronal antigen MM2

Gene Names: PNMA2

Research Areas: Tags & Cell Markers

Organism: Homo sapiens (Human)

AA Sequence: ALALLEDWCRIMSVDEQKSLMVTGIPADFEEAEIQEVLQETLKSLGRYRLLGKIFRKQENANAVLLELLEDTDVSAIPSEVQGKGGVWKVIFKTPNQDTEFLERLNLFLEKEGQTVSGMFRALGQEGVSPATVPCISPELLAHLLGQAMAHAPQPLLPMRYRKLRVFSGSAVPAPEEESFEVWLEQATEIVKEWPVTEAEKKRWLAESLRGPALDLMHIVQADNPSISVEECLEAFKQVFGSLESRRTAQVRYLKTYQEEGEKVSAYVLRLETLLRRAVEKRAIPRRIADQVRLEQVMAGATLNQMLWCRLRELKDQGPPPSFLELMKVIREEEEEEASFENESIEEPEERDGYGRWNHE

Source: E.coli

Tag Info: N-terminal 6xHis-SUMO-tagged

Expression Region: 2-361aa

Sequence Info: Partial

MW: 57.1 kDa

Purity: Greater than 85% as determined by SDS-PAGE.

Relevance: Antibodies against PNMA2 are present in sera from patients suffering of paraneoplastic neurological disorders.

Reference: "A serologic marker of paraneoplastic limbic and brain-stem encephalitis in patients with testicular cancer." Voltz R., Gultekin S.H., Rosenfeld M.R., Gerstner E., Eichen J., Posner J.B., Dalmau J. N. Engl. J. Med. 340:1788-1795(1999)

Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20?/-80?. The shelf life of lyophilized form is 12 months at -20?/-80?.

Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week.

Function:

Involvement in disease:

Subcellular Location: Nucleus, nucleolus

Protein Families: PNMA family

Tissue Specificity: Brain-specific. In some cancer patients, specifically expressed by testicular tumor cells.

Paythway:

Form: Liquid or Lyophilized powder

Buffer: If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.

Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20?/-80?. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Uniprot ID: Q9UL42

HGNC Database Link: HGNC

UniGene Database Link: UniGene

KEGG Database Link: KEGG

STRING Database Link: STRING

OMIM Database Link: OMIM