Recombinant Human Non-histone chromosomal protein HMG-17 (HMGN2) | CSB-EP010570HU

Recombinant Human Non-histone chromosomal protein HMG-17 (HMGN2) | CSB-EP010570HU | Cusabio

Alternative Name(s): High mobility group nucleosome-binding domain-containing protein 2

Gene Names: HMGN2

Research Areas: Others

Organism: Homo sapiens (Human)

AA Sequence: PKRKAEGDAKGDKAKVKDEPQRRSARLSAKPAPPKPEPKPKKAPAKKGEKVPKGKKGKADAGKEGNNPAENGDAKTDQAQKAEGAGDAK

Source: E.coli

Tag Info: N-terminal GST-tagged

Expression Region: 1-90aa

Sequence Info: Full Length

MW: 36.3 kDa

Purity: Greater than 90% as determined by SDS-PAGE.

Relevance: Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation

Reference: "Chromosomal protein HMG-17. Complete human cDNA sequence and evidence for a multigene family." Landsman D., Soares N., Gonzalez F.J., Bustin M. J. Biol. Chem. 261:7479-7484(1986)

Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20?/-80?. The shelf life of lyophilized form is 12 months at -20?/-80?.

Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week.

Function: Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation (By similarity).

Involvement in disease:

Subcellular Location: Nucleus, Cytoplasm

Protein Families: HMGN family

Tissue Specificity:

Paythway:

Form: Liquid or Lyophilized powder

Buffer: If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.

Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20?/-80?. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Uniprot ID: P05204

HGNC Database Link: HGNC

UniGene Database Link: UniGene

KEGG Database Link: KEGG

STRING Database Link: STRING

OMIM Database Link: OMIM