Recombinant Human Noggin protein (NOG) (Active) | CSB-AP003011HU

Recombinant Human Noggin protein (NOG) (Active) | CSB-AP003011HU | Cusabio

Protein Description: Full Length of Mature Protein

Alternative Name (s) :

Gene Names: NOG

Research Areas: Stem Cells

Species: Homo sapiens (Human)

Source: E.Coli

Tag Info: Tag-Free

Expression Region: M+28-232aa

Sequence Info: M+QHYLHIRPA PSDNLPLVDL IEHPDPIFDP KEKDLNETLL RSLLGGHYDP GFMATSPPED RPGGGGGAAG GAEDLAELDQ LLRQRPSGAM PSEIKGLEFS EGLAQGKKQR LSKKLRRKLQ MWLWSQTFCP VLYAWNDLGS RFWPRYVKVG SCFSKRSCSV PEGMVCKPSK SVHLTVLRWR CQRRGGQRCG WIPIQYPIIS ECKCSC

Biological Activity: Fully biologically active when compared to standard. The ED50 as determined by inhibiting BMP-4- induced alkaline phosphatase production of murine ATDC5 cells is less than 3.0 ng/ml, corresponding to a specific activity of ＞ 3.3 × 105 IU/mg in the presence of 5 ng/ml rHuBMP-4.

MW: 23.2 kDa

Purity: >95% as determined by SDS-PAGE and HPLC.

Endotoxin: Less than 1.0 EU/µg as determined by LAL method.

Relevance: Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. Essential for cartilage morphogenesis and joint formation. Inhibits chondrocyte differentiation through its interaction with GDF5 (PubMed:21976273) . {ECO:0000269|PubMed:12478285, ECO:0000269|PubMed:21976273}.

PubMed ID: 7666191; 15489334; 21976273; 24098149; 12478285; 10080184; 11846737; 11545688; 12089654; 11857750; 15770128; 17668388; 20503332

Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.

Function: Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. Essential for cartilage morphogenesis and joint formation. Inhibits chondrocyte differentiation through its interaction with GDF5 and, probably, GDF6

Involvement in disease: Symphalangism, proximal 1A (SYM1A) ; Multiple synostoses syndrome 1 (SYNS1) ; Tarsal-carpal coalition syndrome (TCC) ; Stapes ankylosis with broad thumb and toes (SABTS) ; Brachydactyly B2 (BDB2)

Subcellular Location: Secreted

Protein Families: Noggin family

Tissue Specificity:

Paythway: TGF-betasignalingpathway

Form: Lyophilized powder

Buffer: Lyophilized from a 0.2 μm filtered 30 % acetonitrile, 0.1 % TFA

Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Uniprot ID: Q13253

Uniprot Entry Name: NOGG_HUMAN

HGNC Database Link: HGNC

UniGene Database Link: UniGene

KEGG Database Link: KEGG

STRING Database Link: STRING

OMIM Database Link: OMIM