Recombinant Human natriuretic peptide B (NPPB), partial | CSB-EP016021HU(A5)

Recombinant Human natriuretic peptide B (NPPB), partial | CSB-EP016021HU(A5) | Cusabio

Alternative Name(s): Gamma-brain natriuretic peptide

Gene Names: NPPB

Research Areas: Signal Transduction

Organism: Homo sapiens (Human)

AA Sequence: DLETSGLQEQRNHLQGKLSELQVEQTSLEPLQESP

Source: E.coli

Tag Info: N-terminal GST-tagged

Expression Region: 37-71aa

Sequence Info: Partial

MW: 31 kDa

Purity: Greater than 90% as determined by SDS-PAGE.

Relevance: Cardiac hormone which may function as a paracrine antifibrotic factor in the heart. Also plays a key role in cardiovascular homeostasis through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3.

Reference: "Human and canine gene homologs of porcine brain natriuretic peptide." Seilhamer J.J., Arfsten A., Miller J.A., Lundquist P., Scarborough R.M., Lewicki J.A., Porter J.G. Biochem. Biophys. Res. Commun. 165:650-658(1989)

Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20?/-80?. The shelf life of lyophilized form is 12 months at -20?/-80?.

Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week.

Function: Cardiac hormone which may function as a paracrine antifibrotic factor in the heart. Also plays a key role in cardiovascular homeostasis through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3.

Involvement in disease:

Subcellular Location: Secreted

Protein Families: Natriuretic peptide family

Tissue Specificity: Brain and also in atria, but at much lower levels than ANP.

Paythway: cGMP-PKGsignalingpathway

Form: Liquid or Lyophilized powder

Buffer: If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.

Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20?/-80?. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Uniprot ID: P16860

HGNC Database Link: HGNC

UniGene Database Link: UniGene

KEGG Database Link: KEGG

STRING Database Link: STRING

OMIM Database Link: OMIM