Recombinant Human Mitochondrial fission factor (MFF), partial | CSB-EP013751HU

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CSB-EP013751HU
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  • Recombinant Human Mitochondrial fission factor (MFF), partial
  • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
€352.00 - €1,702.00

Description

Recombinant Human Mitochondrial fission factor (MFF), partial | CSB-EP013751HU | Cusabio

Alternative Name(s): C2orf33

Gene Names: MFF

Research Areas: Others

Organism: Homo sapiens (Human)

AA Sequence: MSKGTSSDTSLGRVSRAAFPSPTAAEMAEISRIQYEMEYTEGISQRMRVPEKLKVAPPNADLEQGFQEGVPNASVIMQVPERIVVAGNNEDVSFSRPADLDLIQSTPFKPLALKTPPRVLTLSERPLDFLDLERPPTTPQNEEIRAVGRLKRERSMSENAVRQNGQLVRNDSLWHRSDSAPRNKISRFQAPISAPEYTVTPSPQQARVCPPHMLPEDGANLSSARGILSLIQSSTRRAYQQILDVLDENRRPVLRGGSAAATSNPHHDNVRYGISNIDTTIEGTSDDLTVVDAASLRRQIIKLNRRLQLLEEENKERAKREM

Source: E.coli

Tag Info: N-terminal 6xHis-tagged

Expression Region: 1-322aa

Sequence Info: Partial

MW: 39.9 kDa

Purity: Greater than 85% as determined by SDS-PAGE.

Relevance: Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface. May be involved in regulation of synaptic vesicle membrane dynamics by recruitment of DNM1L to clathrin-containing vesicles.

Reference: "The novel tail-anchored membrane protein Mff controls mitochondrial and peroxisomal fission in mammalian cells." Gandre-Babbe S., van der Bliek A.M. Mol. Biol. Cell 19:2402-2412(2008)

Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20?/-80?. The shelf life of lyophilized form is 12 months at -20?/-80?.

Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week.

Function: Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface. May be involved in regulation of synaptic vesicle membrane dynamics by recruitment of DNM1L to clathrin-containing vesicles.

Involvement in disease: Encephalopathy due to defective mitochondrial and peroxisomal fission 2 (EMPF2)

Subcellular Location: Mitochondrion outer membrane, Single-pass type IV membrane protein, Peroxisome, Cytoplasmic vesicle, secretory vesicle, synaptic vesicle

Protein Families: Tango11 family

Tissue Specificity: Highly expressed in heart, kidney, liver, brain, muscle, and stomach.

Paythway:

Form: Liquid or Lyophilized powder

Buffer: If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.

Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20?/-80?. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Uniprot ID: Q9GZY8

HGNC Database Link: HGNC

UniGene Database Link: UniGene

KEGG Database Link: KEGG

STRING Database Link: STRING

OMIM Database Link: OMIM

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