Recombinant Human Matrix Gla protein (MGP) | CSB-EP013789HUb1

Recombinant Human Matrix Gla protein (MGP) | CSB-EP013789HUb1 | Cusabio

Alternative Name(s): Cell growth-inhibiting gene 36 protein

Gene Names: MGP

Research Areas: Signal Transduction

Organism: Homo sapiens (Human)

AA Sequence: YESHESMESYELNPFINRRNANTFISPQQRWRAKVQERIRERSKPVHELNREACDDYRLCERYAMVYGYNAAYNRYF

Source: E.coli

Tag Info: N-terminal 10xHis-tagged and C-terminal Myc-tagged

Expression Region: 20-96aa

Sequence Info: Full Length of Mature Protein

MW: 14.5 kDa

Purity: Greater than 90% as determined by SDS-PAGE.

Relevance: Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation.

Reference: "Overexpression of matrix Gla protein mRNA in malignant human breast cells: isolation by differential cDNA hybridization." Chen L., O'Bryan J.P., Smith H.S., Liu E. Oncogene 5:1391-1395(1990)

Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20?/-80?. The shelf life of lyophilized form is 12 months at -20?/-80?.

Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week.

Function: Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation.

Involvement in disease: Keutel syndrome (KTLS)

Subcellular Location: Secreted

Protein Families: Osteocalcin/matrix Gla protein family

Tissue Specificity:

Paythway:

Form: Liquid or Lyophilized powder

Buffer: If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.

Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20?/-80?. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Uniprot ID: P08493

HGNC Database Link: HGNC

UniGene Database Link: UniGene

KEGG Database Link: KEGG

STRING Database Link: N/A

OMIM Database Link: OMIM