Recombinant Human Macrophage mannose receptor 1 (MRC1), partial | CSB-EP014783HUa0

Recombinant Human Macrophage mannose receptor 1 (MRC1), partial | CSB-EP014783HUa0 | Cusabio

Alternative Name(s): C-type lectin domain family 13 member D C-type lectin domain family 13 member D-like Human mannose receptor Short name:hMR Macrophage mannose receptor 1-like protein 1 CD_antigen: CD206 CLEC13D, CLEC13DL, MRC1L1

Gene Names: MRC1

Research Areas: Immunology

Organism: Homo sapiens (Human)

AA Sequence: RTSLCFKLYAKGKHEKKTWFESRDFCRALGGDLASINNKEEQQTIWRLITASGSYHKLFWLGLTYGSPSEGFTWSDGSPVSYENWAYGEPNNYQNVEYCGELKGDPTMSWNDINCEHLNNWICQIQKGQTPKPEPTPAPQDNPPVTEDGWVIYKDYQYYFSKEKETMDNARAFCKRNFGDLVSIQSESEKKFLWKYVNRNDAQSAYFIGLLISLDKKFAWMDGSKVDYVSWATGEPNFANEDENCVTMYSNSGFWNDINCGYPNAFICQRHNSSINATTVMPTMPSVPSGCKEGWNFYSNKCFKIFGFMEEERKNWQEARKACIGFGGNLVSIQNEKEQAFLTYHMKDSTFSAWTGLNDVNSEHTFLWTDGRGVHYTNWGKGYPGGRRSSLSYEDADCVVIIGGASNEAGKWMDDTCDSKRGYICQTRSDPSLTNPPATIQTDGFVKYGKSSYSLMRQKFQWHEAETYCKLHNSLIASILDPYSNAFAWLQMETSNERVWIALNSNLTDNQYTWTDKWRVRYTNWAADEPKLKSACVYLDLDGYWKTAHCNESFYFLCK

Source: E.coli

Tag Info: N-terminal 6xHis-tagged

Expression Region: 655-1213aa

Sequence Info: Partial

MW: 69.9 kDa

Purity: Greater than 85% as determined by SDS-PAGE.

Relevance: Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains. (Microbial infection) Acts as phagocytic receptor for bacteria, fungi and other pathogens. Acts as a receptor for Dengue virus envelope protein E. Interacts with hepatitis B virus envelope protein

Reference: "Primary structure of the mannose receptor contains multiple motifs resembling carbohydrate-recognition domains." Taylor M.E., Conary J.T., Lennartz M.R., Stahl P.D., Drickamer K. J. Biol. Chem. 265:12156-12162(1990)

Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20?/-80?. The shelf life of lyophilized form is 12 months at -20?/-80?.

Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week.

Function: Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains.; FUNCTION

Involvement in disease:

Subcellular Location: Endosome membrane, Single-pass type I membrane protein, Cell membrane, Single-pass type I membrane protein

Protein Families:

Tissue Specificity:

Paythway:

Form: Liquid or Lyophilized powder

Buffer: If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.

Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20?/-80?. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Uniprot ID: P22897

HGNC Database Link: HGNC

UniGene Database Link: UniGene

KEGG Database Link: KEGG

STRING Database Link: STRING

OMIM Database Link: OMIM