Recombinant Human Lysyl oxidase homolog 1 (LOXL1), partial | CSB-EP013040HU

Recombinant Human Lysyl oxidase homolog 1 (LOXL1), partial | CSB-EP013040HU | Cusabio

Alternative Name(s): Lysyl oxidase-like protein 1 ;LOL

Gene Names: LOXL1

Research Areas: Metabolism

Organism: Homo sapiens (Human)

AA Sequence: VGSDTVRGQARHPFGFGQVPDNWREVAVGDSTGMARARTSVSQQRHGGSASSVSASAFASTYRQQPSYPQQFPYPQAPFVSQYENYDPASRTYDQGFVYYRPAGGGVGAGAAAVASAGVIYPYQPRARYEEYGGGEELPEYPPQGFYPAPERPYVPPPPPPPDGLDRRYSHSLYSEGTPGFEQAYPDPGPEAAQAHGGDPRLGWYPPYANPPPEAYGPPRALEPPYLPVRSSDTPPPGGERNGAQQGRLSVGSVYRPNQNGRGLPDLVPDPNYVQASTYVQRAHLYSLRCAAEEKCLASTAYAPEATDYDVRVLLRFPQRVKNQGTADFLPNRPRHTWEWHSCHQHYHSMDEFSHYDLLDAATGKKVAEGHKASFCLEDSTCDFGNLKRYACTSHTQGLSPGCYDTYNADIDCQWIDITDVQPGNYILKVHVNPKYIVLESDFTNNVVRCNIHYTGRYVSATNCKIVQS

Source: E.coli

Tag Info: N-terminal 6xHis-tagged

Expression Region: 106-574aa

Sequence Info: Partial

MW: 55.8 kDa

Purity: Greater than 90% as determined by SDS-PAGE.

Relevance: Active on elastin and collagen substrates.

Reference: Association of LOXL1 gene with Finnish exfoliation syndrome patients.Lemmela S., Forsman E., Onkamo P., Nurmi H., Laivuori H., Kivela T., Puska P., Heger M., Eriksson A., Forsius H., Jarvela I.J. Hum. Genet. 54:289-297(2009)

Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20?/-80?. The shelf life of lyophilized form is 12 months at -20?/-80?.

Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week.

Function: Active on elastin and collagen substrates.

Involvement in disease: Exfoliation syndrome (XFS)

Subcellular Location: Secreted, extracellular space

Protein Families: Lysyl oxidase family

Tissue Specificity: Expressed in ocular tissues including the iris, ciliary body, lens and optic nerve. Not detected in the retina.

Paythway:

Form: Liquid or Lyophilized powder

Buffer: If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.

Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20?/-80?. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Uniprot ID: Q08397

HGNC Database Link: HGNC

UniGene Database Link: UniGene

KEGG Database Link: KEGG

STRING Database Link: STRING

OMIM Database Link: OMIM