Cusabio Human Recombinants
Recombinant Human Keratin, type II cuticular Hb5 (KRT85) | CSB-YP012580HU
- SKU:
- CSB-YP012580HU
- Availability:
- 25 - 35 Working Days
Description
Recombinant Human Keratin, type II cuticular Hb5 (KRT85) | CSB-YP012580HU | Cusabio
Alternative Name(s): Hair keratin K2.12 (Keratin-85) (K85) (Type II hair keratin Hb5) (Type-II keratin Kb25) (KRTHB5)
Gene Names: KRT85
Research Areas: Others
Organism: Homo sapiens (Human)
AA Sequence: MSCRSYRISSGCGVTRNFSSCSAVAPKTGNRCCISAAPYRGVSCYRGLTGFGSRSLCNLGSCGPRIAVGGFRAGSCGRSFGYRSGGVCGPSPPCITTVSVNESLLTPLNLEIDPNAQCVKQEEKEQIKSLNSRFAAFIDKVRFLEQQNKLLETKWQFYQNQRCCESNLEPLFSGYIETLRREAECVEADSGRLASELNHVQEVLEGYKKKYEEEVALRATAENEFVVLKKDVDCAYLRKSDLEANVEALVEESSFLRRLYEEEIRVLQAHISDTSVIVKMDNSRDLNMDCIIAEIKAQYDDVASRSRAEAESWYRSKCEEMKATVIRHGETLRRTKEEINELNRMIQRLTAEIENAKCQRAKLEAAVAEAEQQGEAALSDARCKLAELEGALQKAKQDMACLLKEYQEVMNSKLGLDIEIATYRRLLEGEEHRLCEGVGSVNVCVSSSRGGVSCGGLSYSTTPGRQITSGPSAIGGSITVVAPDSCAPCQPRSSSFSCGSSRSVRFA
Source: Yeast
Tag Info: N-terminal 6xHis-tagged
Expression Region: 1-507aa
Sequence Info: Full Length
MW: 57.1 kDa
Purity: Greater than 85% as determined by SDS-PAGE.
Relevance:
Reference: "SPRR1 gene induction and barrier formation occur as coordinated moving fronts in terminally differentiating epithelia." Marshall D., Hardman M.J., Byrne C. J. Invest. Dermatol. 114:967-975(2000)
Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20?/-80?. The shelf life of lyophilized form is 12 months at -20?/-80?.
Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week.
Function:
Involvement in disease: Ectodermal dysplasia 4, hair/nail type (ECTD4)
Subcellular Location:
Protein Families: Intermediate filament family
Tissue Specificity: Synthesis occurs immediately above a small population of matrix cells at the base of the hair bulb and the trichocytes lining the dermal papilla and extends upward through the matrix and ends in the lower part of the cortex of the hair shaft.
Paythway:
Form: Liquid or Lyophilized powder
Buffer: If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20?/-80?. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Uniprot ID: P78386
HGNC Database Link: HGNC
UniGene Database Link: UniGene
KEGG Database Link: KEGG
STRING Database Link: STRING
OMIM Database Link: OMIM