Recombinant Human Interleukin-4 protein (IL4) (Active) | CSB-AP001711HU
- 5 to 10 Working Days
Recombinant Human Interleukin-4 protein (IL4) (Active) | CSB-AP001711HU | Cusabio
Protein Description: Full Length of Mature Protein
Alternative Name (s) : IL-4, BSF-1, Binetrakin, Lymphocyte stimulatory factor 1, Pitrakinra
Gene Names: IL4
Research Areas: Immunology
Species: Homo sapiens (Human)
Tag Info: Tag-Free
Expression Region: 25-153aa
Sequence Info: HKCDITLQEI IKTLNSLTEQ KTLCTELTVT DIFAASKNTT EKETFCRAAT VLRQFYSHHE KDTRCLGATA QQFHRHKQLI RFLKRLDRNL WGLAGLNSCP VKEANQSTLE NFLERLKTIM REKYSKCSS
Biological Activity: Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using human TF-1 cells is less than 0.2 ng/ml, corresponding to a specific activity of ＞ 5.0 × 106 IU/mg.
MW: 15.0 kDa
Purity: >98% as determined by SDS-PAGE and HPLC.
Endotoxin: Less than 1.0 EU/µg as determined by LAL method.
Relevance: Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes.
PubMed ID: 3016727; 2535858; 7806280; 15489334; 3257560; 1993171; 1400355; 1511746; 10219247; 1932028; 1569578; 1567880; 1567881; 1609277; 1946344; 8151703; 7664036; 14681304
Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Function: Participates in at least several B-cell activation processes as well as of other cell types
Involvement in disease: Ischemic stroke (ISCHSTR)
Subcellular Location: Secreted
Protein Families: IL-4/IL-13 family
Form: Lyophilized powder
Buffer: Lyophilized from a 0.2 µm filtered PBS, pH 7.4
Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Uniprot ID: P05112
Uniprot Entry Name: IL4_HUMAN
HGNC Database Link: HGNC
UniGene Database Link: UniGene
KEGG Database Link: KEGG
STRING Database Link: STRING
OMIM Database Link: OMIM