Recombinant Human Interleukin-17F protein (IL17F) (Active) | CSB-AP001841HU

Recombinant Human Interleukin-17F protein (IL17F) (Active) | CSB-AP001841HU | Cusabio

Protein Description: Full Length of Mature Protein

Alternative Name (s) : IL-17F,

Gene Names: IL17F

Research Areas: Immunology

Species: Homo sapiens (Human)

Source: E.Coli

Tag Info: Tag-Free

Expression Region: 31-163aa

Sequence Info: M+RKIPKVGHT FFQKPESCPP VPGGSMKLDI GIINENQRVS MSRNIESRST SPWNYTVTWD PNRYPSEVVQ AQCRNLGCIN AQGKEDISMN SVPIQQETLV VRRKHQGCSV SFQLEKVLVT VGCTCVTPVI HHVQ

Biological Activity: Fully biologically active when compared to standard. The ED50 as determined by inducing IL-6 secretion of murine NIH/3T3 cells is less than 20 ng/ml, corresponding to a specific activity of ＞ 5.0 × 104 IU/mg.

MW: 15 kDa

Purity: >95% as determined by SDS-PAGE and HPLC.

Endotoxin: Less than 1.0 EU/µg as determined by LAL method.

Relevance: Stimulates the production of other cytokines such as IL-6, IL-8 and granulocyte colony-stimulating factor, and can regulate cartilage matrix turnover. Stimulates PBMC and T-cell proliferation. Inhibits angiogenesis.

PubMed ID: 11591732; 14574404; 15489334; 11591768; 15340161; 11574464; 19838198; 21350122

Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.

Function: Ligand for IL17RA and IL17RC

Involvement in disease: Candidiasis, familial, 6 (CANDF6)

Subcellular Location: Secreted

Protein Families: IL-17 family

Tissue Specificity: Expressed in activated, but not resting, CD4+ T-cells and activated monocytes.

Paythway: IL-17signalingpathway

Form: Lyophilized powder

Buffer: Lyophilized from a 0.2 µm filtered PBS, pH 7.4

Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Uniprot ID: Q96PD4

Uniprot Entry Name: IL17F_HUMAN

HGNC Database Link: HGNC

UniGene Database Link: UniGene

KEGG Database Link: KEGG

STRING Database Link: STRING

OMIM Database Link: OMIM