Cusabio Active Proteins
Recombinant Human Interleukin-17F (IL17F) (Active) | CSB-AP004591HU
- 5 to 10 Working Days
Recombinant Human Interleukin-17F (IL17F) (Active) | CSB-AP004591HU | Cusabio
Protein Description: Full Length of Mature Protein
Alternative Name (s) : Interleukin-17F; IL-17F; Cytokine ML-1; Interleukin-24; IL-24; IL17F; IL24
Gene Names: IL17F
Research Areas: Immunology
Species: Homo sapiens (Human)
Tag Info: Tag-Free
Expression Region: 31-163aa
Sequence Info: RKIPKVGHTFFQKPESCPPVPGGSMKLDIGIINENQRVSMSRNIESRSTSPWNYTVTWDPNRYPSEVVQAQCRNLGCINAQGKEDISMNSVPIQQETLVVRRKHQGCSVSFQLEKVLVTVGCTCVTPVIHHVQ
Biological Activity: The ED50 as determined by its ability to induce IL-6 secretion by NIH‑3T3 mouse embryonic fibroblast cells is less than 40 ng/mL.
MW: 14.9 kDa
Purity: Greater than 95% as determined by SDS-PAGE.
Endotoxin: Less than 1.0 EU/µg as determined by LAL method.
Relevance: Interleukin-17 is a potent pro-inflammatory cytokine produced by activated memory T cells. There are at least six members of the IL-17 family in humans and in mice. Today, IL-17 represents a family of structurally related cytokines that share a highly conserved C-terminal region but differ from one another in their N-terminal regions and in their distinct biological roles. The six known members of this family, IL-17A through IL-17F, are secreted as homodimers. IL-17F also regulates cartilage matrix turnover and inhibits angiogenesis.
Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Function: Ligand for IL17RA and IL17RC
Involvement in disease: Candidiasis, familial, 6 (CANDF6)
Subcellular Location: Secreted
Protein Families: IL-17 family
Tissue Specificity: Expressed in activated, but not resting, CD4+ T-cells and activated monocytes.
Form: Lyophilized powder
Buffer: Lyophilized from a 0.2 μm filtered 20 mM PB, pH 7.4
Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Uniprot ID: Q96PD4
Uniprot Entry Name:
HGNC Database Link: HGNC
UniGene Database Link: UniGene
KEGG Database Link: KEGG
STRING Database Link: STRING
OMIM Database Link: OMIM