Recombinant Human Interleukin-17A protein (IL17A) (Active) | CSB-AP001851HU

Recombinant Human Interleukin-17A protein (IL17A) (Active) | CSB-AP001851HU | Cusabio

Protein Description: Full Length of Mature Protein

Alternative Name (s) : IL-17, Cytotoxic T-lymphocyte-associated antigen 8, CTLA-8

Gene Names: IL17A,CTLA8,IL17

Research Areas: Immunology

Species: Homo sapiens (Human)

Source: E.Coli

Tag Info: Tag-Free

Expression Region: 24-155aa

Sequence Info: GITIPRNPGC PNSEDKNFPR TVMVNLNIHN RNTNTNPKRS SDYYNRSTSP WNLHRNEDPE RYPSVIWEAK CRHLGCINAD GNVDYHMNSV PIQQEILVLR REPPHCPNSF RLEKILVSVG CTCVTPIVHH VA

Biological Activity: Fully biologically active when compared to standard. The ED50 as determined by inducing IL-6 secretion of murine NIH/3T3 cells is less than 7.5 ng/ml, corresponding to a specific activity of ＞ 1.3 × 105 IU/mg.

MW: 15.1 kDa

Purity: >95% as determined by SDS-PAGE and HPLC.

Endotoxin: Less than 1.0 EU/µg as determined by LAL method.

Relevance: Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts.

PubMed ID: 8676080; 7499828; 14574404; 15489334; 15340161; 19835883

Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.

Function: Ligand for IL17RA and IL17RC

Involvement in disease:

Subcellular Location: Secreted

Protein Families: IL-17 family

Tissue Specificity: Restricted to activated memory T-cells.

Paythway: IL-17signalingpathway

Form: Lyophilized powder

Buffer: Lyophilized from a 0.2 µm filtered PBS, pH 7.4

Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Uniprot ID: Q16552

Uniprot Entry Name: IL17_HUMAN

HGNC Database Link: HGNC

UniGene Database Link: UniGene

KEGG Database Link: KEGG

STRING Database Link: STRING

OMIM Database Link: OMIM