Recombinant Human Desert hedgehog protein (DHH), partial (Active) | CSB-AP000411HU
- 5 to 10 Working Days
Recombinant Human Desert hedgehog protein (DHH) ,partial (Active) | CSB-AP000411HU | Cusabio
Protein Description: Partial
Alternative Name (s) : DHH,
Gene Names: DHH
Research Areas: Stem Cells
Species: Homo sapiens (Human)
Tag Info: Tag-Free
Expression Region: 24-198aa
Sequence Info: II+GPGRGPVG RRRYARKQLV PLLYKQFVPG VPERTLGASG PAEGRVARGS ERFRDLVPNY NPDIIFKDEE NSGADRLMTE RCKERVNALA IAVMNMWPGV RLRVTEGWDE DGHHAQDSLH YEGRALDITT SDRDRNKYGL LARLAVEAGF DWVYYESRNH VHVSVKADNS LAVRAGG
Biological Activity: Fully biologically active when compared to standard. The ED50 as determined by its ability to induce alkaline phosphatase production by C3H10T1/2 (CCL-226) cells is 15-45 μg/ml.
MW: 19.9 kDa
Purity: >96% as determined by SDS-PAGE and HPLC.
Endotoxin: Less than 1.0 EU/µg as determined by LAL method.
Relevance: Intercellular signal essential for a variety of patterning events during development. May function as a spermatocyte survival factor in the testes. Essential for testes development.
PubMed ID: 15489334; 11017805; 19561611; 20519495; 15356051
Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Function: Intercellular signal essential for a variety of patterning events during development. May function as a spermatocyte survival factor in the testes. Essential for testes development.
Involvement in disease: Partial gonadal dysgenesis with minifascicular neuropathy 46,XY (PGD) ; 46,XY sex reversal 7 (SRXY7)
Subcellular Location: Desert hedgehog protein N-product: Cell membrane, Lipid-anchor, Extracellular side, Note=The N-terminal peptide remains associated with the cell surface, SUBCELLULAR LOCATION: Desert hedgehog protein C-product: Secreted, extracellular space
Protein Families: Hedgehog family
Form: Lyophilized powder
Buffer: Lyophilized from a 0.2 μm filtered 10mM PB, pH 6.0, 300mM NaCl
Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Uniprot ID: O43323
Uniprot Entry Name: DHH_HUMAN
HGNC Database Link: HGNC
UniGene Database Link: UniGene
KEGG Database Link: KEGG
STRING Database Link: STRING
OMIM Database Link: OMIM