Recombinant Human Corticosteroid-binding globulin (SERPINA6) | CSB-YP021062HU

Recombinant Human Corticosteroid-binding globulin (SERPINA6) | CSB-YP021062HU | Cusabio

Alternative Name(s): Serpin A6Transcortin

Gene Names: SERPINA6

Research Areas: Transport

Organism: Homo sapiens (Human)

AA Sequence: MDPNAAYVNMSNHHRGLASANVDFAFSLYKHLVALSPKKNIFISPVSISMALAMLSLGTCGHTRAQLLQGLGFNLTERSETEIHQGFQHLHQLFAKSDTSLEMTMGNALFLDGSLELLESFSADIKHYYESEVLAMNFQDWATASRQINSYVKNKTQGKIVDLFSGLDSPAILVLVNYIFFKGTWTQPFDLASTREENFYVDETTVVKVPMMLQSSTISYLHDSELPCQLVQMNYVGNGTVFFILPDKGKMNTVIAALSRDTINRWSAGLTSSQVDLYIPKVTISGVYDLGDVLEEMGIADLFTNQANFSRITQDAQLKSSKVVHKAVLQLNEEGVDTAGSTGVTLNLTSKPIILRFNQPFIIMIFDHFTWSSLFLARVMNPV

Source: Yeast

Tag Info: N-terminal 6xHis-tagged

Expression Region: 23-405aa

Sequence Info: Full Length of Mature Protein

MW: 44.6 kDa

Purity: Greater than 90% as determined by SDS-PAGE.

Relevance: Major transport protein for glucocorticoids and progestins in the blood of almost all vertebrate species.

Reference: Primary structure of human corticosteroid binding globulin, deduced from hepatic and pulmonary cDNAs, exhibits homology with serine protease inhibitors.Hammond G.L., Smith C.L., Goping I.S., Underhill D.A., Harley M.J., Reventos J., Musto N.A., Gunsalus G.L., Bardin C.W.Proc. Natl. Acad. Sci. U.S.A. 84:5153-5157(1987)

Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20?/-80?. The shelf life of lyophilized form is 12 months at -20?/-80?.

Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week.

Function: Major transport protein for glucocorticoids and progestins in the blood of almost all vertebrate species.

Involvement in disease: Corticosteroid-binding globulin deficiency (CBG deficiency)

Subcellular Location: Secreted

Protein Families: Serpin family

Tissue Specificity: Plasma; synthesized in liver. Has also been identified in a number of glycocorticoid responsive cells.

Paythway:

Form: Liquid or Lyophilized powder

Buffer: If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.

Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20?/-80?. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Uniprot ID: P08185

HGNC Database Link: HGNC

UniGene Database Link: UniGene

KEGG Database Link: KEGG

STRING Database Link: STRING

OMIM Database Link: OMIM