Recombinant Human Complement receptor type 1 (CR1), partial | CSB-EP005932HU
- 3 - 7 Working Days
Recombinant Human Complement receptor type 1 (CR1), partial | CSB-EP005932HU | Cusabio
Alternative Name(s): C3b/C4b receptor CD_antigen: CD35
Gene Names: CR1
Research Areas: Others
Organism: Homo sapiens (Human)
AA Sequence: GQCNAPEWLPFARPTNLTDEFEFPIGTYLNYECRPGYSGRPFSIICLKNSVWTGAKDRCRRKSCRNPPDPVNGMVHVIKGIQFGSQIKYSCTKGYRLIGSSSATCIISGDTVIWDNETPICDRIPCGLPPTITNGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCII
Tag Info: N-terminal GST-tagged
Expression Region: 41-234aa
Sequence Info: Partial
MW: 48.4 kDa
Purity: Greater than 90% as determined by SDS-PAGE.
Relevance: Mediates cellular binding of particles and immune complexes that have activated complement. (Microbial infection) Acts as a receptor for Epstein-Barr virus.
Reference: "Identification of distinct C3b and C4b recognition sites in the human C3b/C4b receptor (CR1, CD35) by deletion mutagenesis."Klickstein L.B., Bartow T.J., Miletic V., Rabson L.D., Smith J.A., Fearon D.T.J. Exp. Med. 168:1699-1717(1988)
Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20?/-80?. The shelf life of lyophilized form is 12 months at -20?/-80?.
Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week.
Function: Mediates cellular binding of particles and immune complexes that have activated complement.; FUNCTION
Involvement in disease:
Subcellular Location: Membrane, Single-pass type I membrane protein
Protein Families: Receptors of complement activation (RCA) family
Tissue Specificity: Present on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells.
Form: Liquid or Lyophilized powder
Buffer: If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20?/-80?. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Uniprot ID: P17927
HGNC Database Link: HGNC
UniGene Database Link: UniGene
KEGG Database Link: KEGG
STRING Database Link: STRING
OMIM Database Link: OMIM