Recombinant Human CD20 (MS4A1) - VLPs (Active)
- 3 to 7 Working Days
Recombinant Human B-lymphocyte antigen CD20 (MS4A1) - VLPs (Active) | CBS-MP015007HU | Cusabio.
CUSABIO's product CSB-MP015007HU is a recombinant human B-lymphocyte antigen CD20-VLP (virus-like particle). It is produced by the expression of the DNA fragment corresponding to 1-297aa of the human CD20 protein in HEK293 cells. This full-length CD20 protein is fused with a 10xHis-tag at the C-terminus. It has been validated to be active. In the functional ELISA, this recombinant CD20 protein can bind to the anti-CD20 antibody. The EC50 is 3.243-7.085 ng/mL. As a VLP, this recombinant CD20 antigen is highly immunogenic and can induce an immune response similar to a natural infection but fail to replicate in the body. It can be used in cancer studies. And it is available now.
The CD20 antigen is a hydrophobic transmembrane protein expressed during B cell differentiation from the pro-B cell phase until the plasma cell stadium. It is therefore a marker for B cells. It is co-expressed on B cells with CD19. CD20 plays an essential role in the regulation of B-cell development and differentiation, B-cell receptor (BCR) signaling, and cell cycle initiation.
Research Areas: Cancer
Uniprot NO: P11836
Gene Names: MS4A1
Species: Homo sapiens (Human)
Source: Mammalian cell
Expression Region: 1-297aa
Protein Description: Full Length
Tag Info: C-terminal 10xHis-tagged
Mol. Weight: 34.4 kDa
Biological Activity: Measured by its binding ability in a functional ELISA. Immobilized human CD20 at 2 μg/mL can bind Anti-CD20 recombinant antibody (CSB-RA015007A1HU), the EC50 is 3.243-7.085 ng/mL.
Endotoxin: Less than 1.0 EU/ug as determined by LAL method.
Buffer: PBS, pH 7.4, 6% trehalose
Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Alternative Name/ Alias: (B-lymphocyte surface antigen B1) (Bp35) (Leukocyte surface antigen Leu-16) (Membrane-spanning 4-domains subfamily A member 1) (CD antigen CD20)
Purity: Testing in progress.