Recombinant Human Anthrax toxin receptor 1 (ANTXR1), partial | CSB-YP001832HU

Recombinant Human Anthrax toxin receptor 1 (ANTXR1), partial | CSB-YP001832HU | Cusabio

Alternative Name(s): Tumor endothelial marker 8

Gene Names: ANTXR1

Research Areas: Tags & Cell Markers

Organism: Homo sapiens (Human)

AA Sequence: EDGGPACYGGFDLYFILDKSGSVLHHWNEIYYFVEQLAHKFISPQLRMSFIVFSTRGTTLMKLTEDREQIRQGLEELQKVLPGGDTYMHEGFERASEQIYYENRQGYRTASVIIALTDGELHEDLFFYSEREANRSRDLGAIVYCVGVKDFNETQLARIADSKDHVFPVNDGFQALQGIIHSILKKSCIEILAAEPSTICAGESFQVVVRGNGFRHARNVDRVLCSFKINDSVTLNEKPFSVEDTYLLCPAPILKEVGMKAALQVSMNDGLSFISSSVIITTTHCSDGS

Source: Yeast

Tag Info: N-terminal 6xHis-tagged

Expression Region: 33-321aa

Sequence Info: Extracellular Domain

MW: 34.4 kDa

Purity: Greater than 90% as determined by SDS-PAGE.

Relevance: Plays a role in cell attachment and migration. Interacts with Extracellular domain matrix proteins and with the actin cytoskeleton. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. Plays a role in the angiogenic response of cultured umbilical vein endothelial cells.

Reference: "Broad expression analysis of human ANTXR1/TEM8 transcripts reveals differential expression and novel splizce variants."Vargas M., Karamsetty R., Leppla S.H., Chaudry G.J.PLoS ONE 7:E43174-E43174(2012)

Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20?/-80?. The shelf life of lyophilized form is 12 months at -20?/-80?.

Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week.

Function: Plays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. Plays a role in the angiogenic response of cultured umbilical vein endothelial cells.

Involvement in disease: Hemangioma, capillary infantile (HCI); GAPO syndrome (GAPO)

Subcellular Location: Cell membrane, Single-pass type I membrane protein, Cell projection, lamellipodium membrane, Single-pass type I membrane protein, Cell projection, filopodium membrane, Single-pass type I membrane protein

Protein Families: ATR family

Tissue Specificity: Detected in umbilical vein endothelial cells (at protein level). Highly expressed in tumor endothelial cells.

Paythway: NOD-likereceptorsignalingpathway

Form: Liquid or Lyophilized powder

Buffer: If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.

Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20?/-80?. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Uniprot ID: Q9H6X2

HGNC Database Link: HGNC

UniGene Database Link: UniGene

KEGG Database Link: KEGG

STRING Database Link: STRING

OMIM Database Link: OMIM