Recombinant Human 3-hydroxyacyl-CoA dehydrogenase type-2 (HSD17B10) | CSB-EP860776HU

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13 - 23 Working Days
  • Recombinant Human 3-hydroxyacyl-CoA dehydrogenase type-2 (HSD17B10)
  • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
$294.00 - $1,532.40


Recombinant Human 3-hydroxyacyl-CoA dehydrogenase type-2 (HSD17B10) | CSB-EP860776HU | Cusabio

Alternative Name(s): 17-beta-hydroxysteroid dehydrogenase 10 (EC: ;17-beta-HSD 103-hydroxy-2-methylbutyryl-CoA dehydrogenase (EC: dehydrogenase type IIEndoplasmic reticulum-associated amyloid beta-peptide-binding protein;Mitochondrial ribonuclease P protein 2 ;Mitochondrial RNase P protein 2Short chain dehydrogenase/reductase family 5C member 1Short-chain type dehydrogenase/reductase XH98G2Type II HADH

Gene Names: HSD17B10

Research Areas: Transcription

Organism: Homo sapiens (Human)


Source: E.coli

Tag Info: N-terminal 6xHis-SUMO-tagged

Expression Region: 2-261aa

Sequence Info: Full Length of Mature Protein

MW: 42.8 kDa

Purity: Greater than 90% as determined by SDS-PAGE.

Relevance: Functions in mitochondrial tRNA maturation. Part of mitochondrial ribonuclease P, an enzyme composed of MRPP1/TRMT10C, MRPP2/HSD17B10 and MRPP3/KIAA0391, which cleaves tRNA molecules in their 5'-ends. Catalyzes the beta-oxidation at position 17 of androgens and estrogens and has 3-alpha-hydroxysteroid dehydrogenase activity with androsterone. Catalyzes the third step in the beta-oxidation of fatty acids. Carries out oxidative conversions of 7-alpha-OH and 7-beta-OH bile acids. Also exhibits 20-beta-OH and 21-OH dehydrogenase activities with C21 steroids. By interacting with intracellular amyloid-beta, it may contribute to the neuronal dysfunction associated with Alzheimer disease (AD).

Reference: An intracellular protein that binds amyloid-beta peptide and mediates neurotoxicity in Alzheimer's disease.Yan S.D., Fu J., Soto C., Chen X., Zhu H., Al-Mohanna F., Collinson K., Zhu A., Stern E., Saido T., Tohyama M., Ogawa S., Roher A., Stern D.Nature 389:689-695(1997)

Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20?/-80?. The shelf life of lyophilized form is 12 months at -20?/-80?.

Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week.

Function: Mitochondrial dehydrogenase that catalyzes the beta-oxidation at position 17 of androgens and estrogens and has 3-alpha-hydroxysteroid dehydrogenase activity with androsterone

Involvement in disease: HDS10 mitochondrial disease (HSD10MD); Mental retardation, X-linked 17 (MRX17)

Subcellular Location: Mitochondrion

Protein Families: Short-chain dehydrogenases/reductases (SDR) family

Tissue Specificity: Ubiquitously expressed in normal tissues but is overexpressed in neurons affected in AD.


Form: Liquid or Lyophilized powder

Buffer: If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.

Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20?/-80?. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Uniprot ID: Q99714

HGNC Database Link: HGNC

UniGene Database Link: UniGene

KEGG Database Link: KEGG

STRING Database Link: STRING

OMIM Database Link: OMIM

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