Recombinant Fruit fly Accessory gland-specific peptide 70A (SP) | CSB-YP356570DLU

Recombinant Fruit fly Accessory gland-specific peptide 70A (SP) | CSB-YP356570DLU | Cusabio

Alternative Name(s): Paragonial peptide B Sex peptide Short name: SP

Gene Names: SP

Research Areas: Others

Organism: Drosophila melanogaster (Fruit fly)

AA Sequence: WEWPWNRKPTKFPIPSPNPRDKWCRLNLGPAWGGRC

Source: Yeast

Tag Info: Tag-Free

Expression Region: 20-55aa

Sequence Info: Full Length of Mature Protein

MW: 4.3 kDa

Purity: Greater than 90% as determined by SDS-PAGE.

Relevance: Male seminal protein which triggers short- and long-term post-mating behavioral responses (PMR) in female Drosophila (PubMed:3135120, PubMed:19249273, PubMed:20308537, PubMed:19793753, PubMed:15694303, PubMed:24089336). Binds initially to sperm where it is later cleaved to release an active peptide within the female reproductive tract. Signals via the sex peptide receptor (SPR) in female flies; may also act via other receptors (PubMed:20458515, PubMed:20308537, PubMed:24089336). Moderates the activity of distinct neuronal circuitries in the female genital tract to promote specific PMRs including: enhanced ovulation, increased egg laying rate, increased feeding/foraging rate, induced antimicrobial peptide synthesis, reduced mating receptivity, reduced day-time sleep and reduced lifespan in multiple mated females (PubMed:3135120, PubMed:15694303, PubMed:19249273, PubMed:19793753, PubMed:24089336).

Reference: "Population genetics of accessory gland proteins and sexual behavior in Drosophila melanogaster populations from Evolution Canyon."Panhuis T.M., Swanson W.J., Nunney L.Evolution 57:2785-2791(2003)

Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20?/-80?. The shelf life of lyophilized form is 12 months at -20?/-80?.

Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week.

Function: Male seminal protein which triggers short- and long-term post-mating behavioral responses (PMR) in female Drosophila

Involvement in disease:

Subcellular Location: Secreted

Protein Families: Drosophila sex peptide family

Tissue Specificity: Main cells of the accessory glands of males (paragonial gland).

Paythway:

Form: Liquid or Lyophilized powder

Buffer: If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.

Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20?/-80?. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Uniprot ID: P05623

HGNC Database Link: N/A

UniGene Database Link: UniGene

KEGG Database Link: KEGG

STRING Database Link: STRING

OMIM Database Link: N/A