PKD2 Antibody | CSB-PA618787LA01HU

PKD2 Antibody | CSB-PA618787LA01HU | Cusabio

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Product Type: Polyclonal Antibody

Target Names: PKD2

Aliases: Polycystin-2 (PC2) (Autosomal dominant polycystic kidney disease type II protein) (Polycystic kidney disease 2 protein) (Polycystwin) (R48321) (Transient receptor potential cation channel subfamily P member 2), PKD2, TRPP2

Background: Functions as a cation channel involved in fluid-flow mechanosensation by the primary cilium in renal epithelium (PubMed:18695040) . Functions as outward-rectifying K (+) channel, but is also permeable to Ca (2+), and to a much lesser degree also to Na (+) (PubMed:11854751, PubMed:15692563, PubMed:27071085, PubMed:27991905) . May contribute to the release of Ca (2+) stores from the endoplasmic reticulum (PubMed:11854751, PubMed:20881056) . Together with TRPV4, forms mechano- and thermosensitive channels in cilium (PubMed:18695040) . PKD1 and PKD2 may function through a common signaling pathway that is necessary to maintain the normal, differentiated state of renal tubule cells. Acts as a regulator of cilium length, together with PKD1. The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling. The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling. Also involved in left-right axis specification via its role in sensing nodal flow; forms a complex with PKD1L1 in cilia to facilitate flow detection in left-right patterning. Detection of asymmetric nodal flow gives rise to a Ca (2+) signal that is required for normal, asymmetric expression of genes involved in the specification of body left-right laterality (By similarity) .

Isotype: IgG

Conjugate: Non-conjugated

Clonality: Polyclonal

Uniport ID: Q13563

Host Species: Rabbit

Species Reactivity: Human

Immunogen: Recombinant Human Polycystin-2 protein (680-968AA)

Immunogen Species: Human

Applications: ELISA, IHC, IF

Tested Applications: ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200

Purification Method: >95%, Protein G purified

Dilution Ratio1: ELISA:1:2000-1:10000

Dilution Ratio2: IHC:1:20-1:200

Dilution Ratio3: IF:1:50-1:200

Dilution Ratio4:

Dilution Ratio5:

Dilution Ratio6:

Buffer: Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form: Liquid

Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Initial Research Areas: Signal Transduction

Research Areas: Metabolism;Signal transduction