PICK1 Antibody, HRP conjugated | CSB-PA05445B0Rb

PICK1 Antibody, HRP conjugated | CSB-PA05445B0Rb | Cusabio

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Product Type: Polyclonal Antibody

Target Names: PICK1

Aliases: PRKCA-binding protein (Protein interacting with C kinase 1) (Protein kinase C-alpha-binding protein), PICK1, PRKCABP

Background: Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competetive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD) . Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function.

Isotype: IgG

Conjugate: HRP

Clonality: Polyclonal

Uniport ID: Q9NRD5

Host Species: Rabbit

Species Reactivity: Human

Immunogen: Recombinant Human PRKCA-binding protein (1-200AA)

Immunogen Species: Human

Applications: ELISA

Tested Applications: ELISA

Purification Method: >95%, Protein G purified

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Buffer: Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form: Liquid

Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Initial Research Areas: Neuroscience

Research Areas: Neuroscience;Signal transduction