PIAS4 Antibody | CSB-PA577177

PIAS4 Antibody | CSB-PA577177 | Cusabio

PIAS4 Antibody is Available at Gentaur Genprice with the fastest delivery.

Online Order Payment is possible or send quotation to info@gentaur.com.

Product Type: Polyclonal Antibody

Target Names: PIAS4

Aliases: PIAS-gamma; PIASG; PIASy; protein inhibitor of activated STAT protein 4; protein inhibitor of activated STAT protein PIASy

Background: Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53/TP53 pathway, the Wnt pathway and the steroid hormone signaling pathway. Involved in gene silencing. Mediates sumoylation of CEBPA, PARK7, HERC2, MYB, TCF4 and RNF168. In Wnt signaling, represses LEF1 and enhances TCF4 transcriptional activities through promoting their sumoylations.

Zendra E. Zehner, AACR Meeting Abstracts, Apr 2005; 2005: 456.
Amador Albor, J. Biol. Chem., Sep 2006; 281: 25850 - 25866.
Christina-Maria Hecker, J. Biol. Chem., Jun 2006; 281: 16117 - 16127.
Yun Zhao, Stem Cells, Apr 2007; 10.1634.

Isotype: IgG

Conjugate: Non-conjugated

Clonality: Polyclonal

Uniport ID: Q8N2W9

Host Species: Rabbit

Species Reactivity: Human, Mouse

Immunogen: Synthesized peptide derived from Internal of human PIAS4.

Immunogen Species: Human

Applications: ELISA, WB, IHC

Tested Applications: ELISA, WB, IHC;WB:1:500-1:3000, IHC:1:50-1:100

Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Dilution Ratio1: ELISA:1:2000-1:10000

Dilution Ratio2: WB:1:500-1:3000

Dilution Ratio3: IHC:1:50-1:100

Dilution Ratio4:

Dilution Ratio5:

Dilution Ratio6:

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form: liquid

Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Initial Research Areas: Epigenetics and Nuclear Signaling

Research Areas: Epigenetics & Nuclear Signaling