Phospho-PRKDC (Thr2609) Antibody | CSB-PA909958

Phospho-PRKDC (Thr2609) Antibody | CSB-PA909958 | Cusabio

Phospho-PRKDC (Thr2609) Antibody is Available at Gentaur Genprice with the fastest delivery.

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Product Type: Polyclonal Antibody

Target Names: PRKDC

Aliases: DNPK1; PRKD; PRKDC; XRCC7; P460

Background: The PRKDC gene encodes the catalytic subunit of a nuclear DNA-dependent serine/threonine protein kinase (DNA-PK) . The second component is the autoimmune antigen Ku (MIM 152690), which is encoded by the G22P1 gene on chromosome 22q. On its own, the catalytic subunit of DNA-PK is inactive and relies on the G22P1 component to direct it to the DNA and trigger its kinase activity; PRKDC must be bound to DNA to express its catalytic properties

Chan DW, et al. (2002) Genes Dev. Sep 15; 16 (18) : 2333-2338
Ding Q, et al. (2003) Mol Cell Biol. Aug; 23 (16) : 5836-5848
Douglas P, et al. (2002) Biochem J. Nov 15; 368 (Pt 1) : 243-251

Isotype: IgG

Conjugate: Non-conjugated

Clonality: Polyclonal

Uniport ID: P78527

Host Species: Rabbit

Species Reactivity: Human

Immunogen: Peptide sequence around phosphorylation site of threonine 2609 (V-E-T (p) -Q-A) derived from Human DNA-PK.

Immunogen Species: Human

Applications: ELISA, WB

Tested Applications: ELISA, WB;WB:1:500-1:1000

Purification Method: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.

Dilution Ratio1: ELISA:1:2000-1:10000

Dilution Ratio2: WB:1:500-1:1000

Dilution Ratio3:

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Buffer: Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form: liquid

Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Initial Research Areas: Epigenetics and Nuclear Signaling

Research Areas: Epigenetics & Nuclear Signaling