Cusabio Recombinant Antibodies
Phospho-NBN (S343) Antibody | CSB-RA015486A343phHU
- SKU:
- CSB-RA015486A343phHU
- Availability:
- 3 to 7 Working Days
Description
Phospho-NBN (S343) Antibody | CSB-RA015486A343phHU | Cusabio
Phospho-NBN (S343) Antibody is Available at Gentaur Genprice with the fastest delivery.
Online Order Payment is possible or send quotation to info@gentaur.com.
Antibody Type: Recombinant Antibody
Target Names: NBN
Aliases: Nibrin, Cell cycle regulatory protein p95, Nijmegen breakage syndrome protein 1, NBN, NBS, NBS1, P95
Background: Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11. RAD50 may be required to bind DNA ends and hold them in close proximity. NBN modulate the DNA damage signal sensing by recruiting PI3/PI4-kinase family members ATM, ATR, and probably DNA-PKcs to the DNA damage sites and activating their functions. It can also recruit MRE11 and RAD50 to the proximity of DSBs by an interaction with the histone H2AX. NBN also functions in telomere length maintenance by generating the 3' overhang which serves as a primer for telomerase dependent telomere elongation. NBN is a major player in the control of intra-S-phase checkpoint and there is some evidence that NBN is involved in G1 and G2 checkpoints. The roles of NBS1/MRN encompass DNA damage sensor, signal transducer, and effector, which enable cells to maintain DNA integrity and genomic stability. Forms a complex with RBBP8 to link DNA double-strand break sensing to resection. Enhances AKT1 phosphorylation possibly by association with the mTORC2 complex.
Isotype: Rabbit IgG
Conjugate: Non-conjugated
Clonality: Monoclonal
Clone Number: 1B4
Uniport ID: O60934
Modified: Epigenetics and Nuclear Signaling
species: Human
Species Reactivity: Human
Immunogen: A synthesized peptide derived from human Phospho-NBN (S343)
Tested Applications: ELISA, WB; Recommended dilution: WB:1:500-1:5000
Purification Method: Affinity-chromatography
Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form: Liquid
Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.