Cusabio Polyclonal Antibodies
Phospho-LATS1/LATS2 (Thr1079/1041) Antibody | CSB-PA905508
- SKU:
- CSB-PA905508
- Availability:
- 3 to 7 Working Days
- Size:
- 100ul
Description
Phospho-LATS1/LATS2 (Thr1079/1041) Antibody | CSB-PA905508 | Cusabio
Phospho-LATS1/LATS2 (Thr1079/1041) Antibody is Available at Gentaur Genprice with the fastest delivery.
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Product Type: Polyclonal Antibody
Target Names: LATS1/LATS2
Aliases: WARTS; Large tumor suppressor 1; EC 2.7.11.1;
Background:
The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding.
Tao W., Nat. Genet. 21:177-181 (1999) .
Nishiyama Y., FEBS Lett. 459:159-165 (1999) .
The MGC Project Team, Genome Res. 14:2121-2127 (2004) .
Isotype: IgG
Conjugate: Non-conjugated
Clonality: Polyclonal
Uniport ID: O95835/Q9NRM7
Host Species: Rabbit
Species Reactivity: Human, Mouse
Immunogen: Peptide sequence around phosphorylation site of threonine 1079/1041 (E-F-T (p) -F-R) derived from Human LATS1/2 .
Immunogen Species: Human
Applications: ELISA, IHC
Tested Applications: ELISA, IHC;IHC:1:50-1:100
Purification Method: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Dilution Ratio1: ELISA:1:2000-1:10000
Dilution Ratio2: IHC:1:50-1:100
Dilution Ratio3:
Dilution Ratio4:
Dilution Ratio5:
Dilution Ratio6:
Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form: liquid
Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Initial Research Areas: Cell Biology
Research Areas: Epigenetics & Nuclear Signaling;Cancer;Cell biology;Signal transduction