Phospho-LATS1/LATS2 (Thr1079/1041) Antibody | CSB-PA905508

Phospho-LATS1/LATS2 (Thr1079/1041) Antibody | CSB-PA905508 | Cusabio

Phospho-LATS1/LATS2 (Thr1079/1041) Antibody is Available at Gentaur Genprice with the fastest delivery.

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Product Type: Polyclonal Antibody

Target Names: LATS1/LATS2

Aliases: WARTS; Large tumor suppressor 1; EC 2.7.11.1;

Background:

The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding.

Tao W., Nat. Genet. 21:177-181 (1999) .
Nishiyama Y., FEBS Lett. 459:159-165 (1999) .
The MGC Project Team, Genome Res. 14:2121-2127 (2004) .

Isotype: IgG

Conjugate: Non-conjugated

Clonality: Polyclonal

Uniport ID: O95835/Q9NRM7

Host Species: Rabbit

Species Reactivity: Human, Mouse

Immunogen: Peptide sequence around phosphorylation site of threonine 1079/1041 (E-F-T (p) -F-R) derived from Human LATS1/2 .

Immunogen Species: Human

Applications: ELISA, IHC

Tested Applications: ELISA, IHC;IHC:1:50-1:100

Purification Method: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.

Dilution Ratio1: ELISA:1:2000-1:10000

Dilution Ratio2: IHC:1:50-1:100

Dilution Ratio3:

Dilution Ratio4:

Dilution Ratio5:

Dilution Ratio6:

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form: liquid

Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Initial Research Areas: Cell Biology

Research Areas: Epigenetics & Nuclear Signaling;Cancer;Cell biology;Signal transduction