Phospho-IRS1 (Ser636) Antibody | CSB-PA577877

Phospho-IRS1 (Ser636) Antibody | CSB-PA577877 | Cusabio

Phospho-IRS1 (Ser636) Antibody is Available at Gentaur Genprice with the fastest delivery.

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Product Type: Polyclonal Antibody

Target Names: IRS1

Aliases: IRS-1; IRS1;

Background: May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit

Ozes ON, et al. (2001) Proc Natl Acad Sci U S A; 98 (8) : 4640-4645
Tzatsos A, et al. (2006) Mol Cell Biol; 26 (1) : 63-76
Kadowaki T, et al. (2000) J Clin Invest; 106 (4) : 459-465
Ozes ON, et al. (2001) Proc Natl Acad Sci U S A; 98 (8) : 4640-4645
Szanto I, et al. (2000) Proc Natl Acad Sci U S A; 97 (5) : 2355-2360

Isotype: IgG

Conjugate: Non-conjugated

Clonality: Polyclonal

Uniport ID: P35568

Host Species: Rabbit

Species Reactivity: Human, Mouse, Rat

Immunogen: Peptide sequence around phosphorylation site of serine 636 (P-M-S (p) -P-K) derived from Human IRS-1.

Immunogen Species: Human

Applications: ELISA, WB, IHC

Tested Applications: ELISA, WB, IHC;WB:1:500-1:1000, IHC:1:50-1:100

Purification Method: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.

Dilution Ratio1: ELISA:1:2000-1:10000

Dilution Ratio2: WB:1:500-1:1000

Dilution Ratio3: IHC:1:50-1:100

Dilution Ratio4:

Dilution Ratio5:

Dilution Ratio6:

Buffer: Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form: liquid

Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Initial Research Areas: Tags & Cell Markers

Research Areas: Neuroscience;Cancer;Cardiovascular;Tags & Cell Markers;Metabolism;Signal transduction