Cusabio Polyclonal Antibodies
Phospho-EIF2AK3 (Thr981) Antibody | CSB-PA072558
- SKU:
- CSB-PA072558
- Availability:
- 3 to 7 Working Days
- Size:
- 100ul
Description
Phospho-EIF2AK3 (Thr981) Antibody | CSB-PA072558 | Cusabio
Phospho-EIF2AK3 (Thr981) Antibody is Available at Gentaur Genprice with the fastest delivery.
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Product Type: Polyclonal Antibody
Target Names: EIF2AK3
Aliases: E2AK3; PERK; PEK; EIF2AK3;
Background:
Phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis. Serves as a critical effector of unfolded protein response (UPR) -induced G1 growth arrest due to the loss of cyclin-D1 (CCND1)
Shi Y., An J., J. Biol. Chem. 274:5723-5730 (1999) .
Sood R., Biochem. J. 346:281-293 (2000) .
The MGC Project Team; Genome Res. 14:2121-2127 (2004) .
Isotype: IgG
Conjugate: Non-conjugated
Clonality: Polyclonal
Uniport ID: Q9NZJ5
Host Species: Rabbit
Species Reactivity: Human, Mouse
Immunogen: Peptide sequence around phosphorylation site of threonine 981 (A-R-H (p) -T-G) derived from Human PEK/PERK.
Immunogen Species: Human
Applications: ELISA, IHC
Tested Applications: ELISA, IHC;IHC:1:50-1:100
Purification Method: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Dilution Ratio1: ELISA:1:2000-1:10000
Dilution Ratio2: IHC:1:50-1:100
Dilution Ratio3:
Dilution Ratio4:
Dilution Ratio5:
Dilution Ratio6:
Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form: liquid
Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Initial Research Areas: Epigenetics and Nuclear Signaling
Research Areas: Epigenetics & Nuclear Signaling;Metabolism