Phospho-CDH5 (Tyr731) Antibody | CSB-PA868788

Phospho-CDH5 (Tyr731) Antibody | CSB-PA868788 | Cusabio

Phospho-CDH5 (Tyr731) Antibody is Available at Gentaur Genprice with the fastest delivery.

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Product Type: Polyclonal Antibody

Target Names: CDH5

Aliases: Vascular endothelial cadherin; VE-cadherin; 7B4 antigen; CDH5; CD144 antigen

Background:

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. It associates with alpha-catenin forming a link to the cytoskeleton. Acts in concert with KRIT1 to establish and maintain correct endothelial cell polarity and vascular lumen.

Wessel F, et al. (2014) Nat Immunol 15, 223-30
Sawada J, et al. (2012) Cancer Cell 22, 235-49
Turowski P, et al. (2008) J Cell Sci 121, 29-37

Isotype: IgG

Conjugate: Non-conjugated

Clonality: Polyclonal

Uniport ID: P33151

Host Species: Rabbit

Species Reactivity: Human, Mouse

Immunogen: Peptide sequence around phosphorylation site of Tyrosine731 (H-I-Y (p) -G-Y) derived from Human VE-Cadherin.

Immunogen Species: Human

Applications: ELISA, WB

Tested Applications: ELISA, WB;WB:1:500-1:1000

Purification Method: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.

Dilution Ratio1: ELISA:1:2000-1:10000

Dilution Ratio2: WB:1:500-1:1000

Dilution Ratio3:

Dilution Ratio4:

Dilution Ratio5:

Dilution Ratio6:

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form: liquid

Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Initial Research Areas: Signal Transduction

Research Areas: Cancer;Cardiovascular;Signal transduction