Phospho-ABL1 (Tyr204) Antibody | CSB-PA984556

Phospho-ABL1 (Tyr204) Antibody | CSB-PA984556 | Cusabio

Phospho-ABL1 (Tyr204) Antibody is Available at Gentaur Genprice with the fastest delivery.

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Product Type: Polyclonal Antibody

Target Names: ABL1

Aliases: p150; c-ABL; EC 2.7.10.2;

Background:

Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation) ; ANXA1 (involved in membrane anchoring) ; DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling) ; or MAPT and PXN (microtubule-binding proteins) .

Meyn MA, et al. (2006) J Biol Chem 281, 30907-16
Steen H, et al. (2003) Mol Cell Proteomics 2, 138-45
Salomon AR, et al. (2003) Proc Natl Acad Sci U S A 100, 443-8

Isotype: IgG

Conjugate: Non-conjugated

Clonality: Polyclonal

Uniport ID: P00519

Host Species: Rabbit

Species Reactivity: Human, Mouse, Rat

Immunogen: Peptide sequence around phosphorylation site of tyrosine 204 (K-L-Y (p) -V-S) derived from Human c-Abl.

Immunogen Species: Human

Applications: ELISA, WB

Tested Applications: ELISA, WB;WB:1:500-1:1000

Purification Method: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.

Dilution Ratio1: ELISA:1:2000-1:10000

Dilution Ratio2: WB:1:500-1:1000

Dilution Ratio3:

Dilution Ratio4:

Dilution Ratio5:

Dilution Ratio6:

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form: liquid

Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Initial Research Areas: Signal Transduction

Research Areas: Epigenetics & Nuclear Signaling;Cancer;Signal transduction