PDE8A Antibody | CSB-PA525315LA01HU

PDE8A Antibody | CSB-PA525315LA01HU | Cusabio

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Product Type: Polyclonal Antibody

Target Names: PDE8A

Aliases: High affinity cAMP-specific and IBMX-insensitive 3', 5'-cyclic phosphodiesterase 8A (EC 3.1.4.53), PDE8A

Background: Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (PubMed:18983167) . May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development (PubMed:18983167) . Binding to RAF1 reduces RAF1 'Ser-259' inhibitory-phosphorylation and stimulates RAF1-dependent EGF-activated ERK-signaling (PubMed:23509299) . Protects against cell death induced by hydrogen peroxide and staurosporine (PubMed:23509299) .

Isotype: IgG

Conjugate: Non-conjugated

Clonality: Polyclonal

Uniport ID: O60658

Host Species: Rabbit

Species Reactivity: Human

Immunogen: Recombinant Human High affinity cAMP-specific and IBMX-insensitive 3', 5'-cyclic phosphodiesterase 8A protein (596-829AA)

Immunogen Species: Homo sapiens (Human)

Applications: ELISA, IHC, IF

Tested Applications: ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200

Purification Method: Antigen Affinity Purified

Dilution Ratio1: ELISA:1:2000-1:10000

Dilution Ratio2: IHC:1:20-1:200

Dilution Ratio3: IF:1:50-1:200

Dilution Ratio4:

Dilution Ratio5:

Dilution Ratio6:

Buffer: Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form: Liquid

Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Initial Research Areas: Signal Transduction

Research Areas: Signal transduction