P Antibody, FITC conjugated | CSB-PA324598LC01HDO
- 3 to 7 Working Days
P Antibody, FITC conjugated | CSB-PA324598LC01HDO | Cusabio
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Product Type: Polyclonal Antibody
Target Names: P
Aliases: Protein P [Includes: DNA-directed DNA polymerase (EC 188.8.131.52) ; RNA-directed DNA polymerase (EC 184.108.40.206) ; Ribonuclease H (EC 220.127.116.11) ], P
Background: Multifunctional enzyme that converts the viral RNA genome into dsDNA in viral cytoplasmic capsids. This enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes in a partially processive 3'- to 5'-endonucleasic mode. Neo-synthesized pregenomic RNA (pgRNA) are encapsidated together with the P protein, and reverse-transcribed inside the nucleocapsid. Initiation of reverse-transcription occurs first by binding the epsilon loop on the pgRNA genome, and is initiated by protein priming, thereby the 5'-end of (-) DNA is covalently linked to P protein. Partial (+) DNA is synthesized from the (-) DNA template and generates the relaxed circular DNA (RC-DNA) genome. After budding and infection, the RC-DNA migrates in the nucleus, and is converted into a plasmid-like covalently closed circular DNA (cccDNA) . The activity of P protein does not seem to be necessary for cccDNA generation, and is presumably released from (+) DNA by host nuclear DNA repair machinery.
Uniport ID: P17100
Host Species: Rabbit
Species Reactivity: Hepatitis B virus genotype A2 subtype adw2
Immunogen: Recombinant Hepatitis B virus genotype A2 subtype adw2 Protein P protein (349-692AA)
Immunogen Species: Hepatitis B virus genotype A2 subtype adw2
Tested Applications: ELISA
Purification Method: >95%, Protein G purified
Buffer: Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Initial Research Areas: Others
Research Areas: Others