OAS1 Antibody, HRP conjugated | CSB-PA640913LB01HU
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OAS1 Antibody, HRP conjugated | CSB-PA640913LB01HU | Cusabio
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Product Type: Polyclonal Antibody
Target Names: OAS1
Aliases: 2'-5'-oligoadenylate synthase 1 ( (2-5') oligo (A) synthase 1) (2-5A synthase 1) (EC 22.214.171.124) (E18/E16) (p46/p42 OAS), OAS1, OIAS
Background: Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. The secreted form displays antiviral effect against vesicular stomatitis virus (VSV), herpes simplex virus type 2 (HSV-2), and encephalomyocarditis virus (EMCV) and stimulates the alternative antiviral pathway independent of RNase L.
Uniport ID: P00973
Host Species: Rabbit
Species Reactivity: Human
Immunogen: Recombinant Human 2'-5'-oligoadenylate synthase 1 protein (296-395AA)
Immunogen Species: Human
Tested Applications: ELISA
Purification Method: >95%, Protein G purified
Buffer: Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Initial Research Areas: Epigenetics and Nuclear Signaling
Research Areas: Epigenetics & Nuclear Signaling