NTHL1 Antibody, Biotin conjugated | CSB-PA016125LD01HU

NTHL1 Antibody, Biotin conjugated | CSB-PA016125LD01HU | Cusabio

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Product Type: Polyclonal Antibody

Target Names: NTHL1

Aliases: Endonuclease III-like protein 1 (hNTH1) (EC 3.2.2.-) (EC 4.2.99.18) (Bifunctional DNA N-glycosylase/DNA- (apurinic or apyrimidinic site) lyase) (DNA glycosylase/AP lyase), NTHL1, NTH1 OCTS3

Background: Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. Has also 8-oxo-7, 8-dihydroguanine (8-oxoG) DNA glycosylase activity. Acts preferentially on DNA damage opposite guanine residues in DNA. Is able to process lesions in nucleosomes without requiring or inducing nucleosome disruption.

Isotype: IgG

Conjugate: Biotin

Clonality: Polyclonal

Uniport ID: P78549

Host Species: Rabbit

Species Reactivity: Human

Immunogen: Recombinant Human Endonuclease III-like protein 1 protein (31-312AA)

Immunogen Species: Human

Applications: ELISA

Tested Applications: ELISA

Purification Method: >95%, Protein G purified

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Buffer: Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form: Liquid

Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Initial Research Areas: Epigenetics and Nuclear Signaling

Research Areas: Epigenetics & Nuclear Signaling